Distinct population and singleneuron selectivity for executive and episodic processing in human dorsal posterior cingulate

Lyndsey Aponik-Gremillion, Yvonne Y. Chen, Eleonora Bartoli, Seth R. Koslov, Hernan G. Rey, Kevin S. Weiner, Daniel Yoshor, Benjamin Y. Hayden, Sameer A. Sheth, Brett L. Foster

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Posterior cingulate cortex (PCC) is an enigmatic region implicated in psychiatric and neurological disease, yet its role in cognition remains unclear. Human studies link PCC to episodic memory and default mode network (DMN), while findings from the non-human primate emphasize executive processes more associated with the cognitive control network (CCN) in humans. We hypothesized this difference reflects an important functional division between dorsal (executive) and ventral (episodic) PCC. To test this, we utilized human intracranial recordings of population and single unit activity targeting dorsal PCC during an alternated executive/episodic processing task. Dorsal PCC population responses were significantly enhanced for executive, compared to episodic, task conditions, consistent with the CCN. Single unit recordings, however, revealed four distinct functional types with unique executive (CCN) or episodic (DMN) response profiles. Our findings provide critical electrophysiological data from human PCC, bridging incongruent views within and across species, furthering our understanding of PCC function.

Original languageEnglish (US)
Article numbere80722
JournaleLife
Volume11
DOIs
StatePublished - Sep 2022

Bibliographical note

Funding Information:
Funder Grant reference number Author National Institute of Mental Health R01MH129439 Brett L Foster Benjamin Y Hayden National Institute of Mental Health R01MH106700 Sameer A Sheth National Eye Institute R01EY023336 Daniel Yoshor National Institute of Mental Health R01MH116914 Brett L Foster Eunice Kennedy Shriver National Institute of Child Health and Human Development R21HD100858 Kevin S Weiner National Science Foundation CAREER Award 2042251 Kevin S Weiner.

Publisher Copyright:
© Aponik-Gremillion et al.

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