Distinct component profiles and high risk among african americans with metabolic syndrome

Herman Taylor, Jiankang Liu, Gregory Wilson, Sherita H. Golden, Errol Crook, Claude D. Brunson, Micheal Steffes, William D. Johnson, Jung Hye Sung

Research output: Contribution to journalArticle

Abstract

OBJECTIVE-Health of African Americans is seriously threatened by unremitting epidemics of diabetes and cardiovascular disease (CVD). However, the role of metabolic syndrome in the African-American population has not been investigated widely. This study examined the prevalence of metabolic syndrome and assessed its cross-sectional relationship to CVD in the Jackson Heart Study (JHS) cohort. RESEARCH DESIGNANDMETHODS-A total of 5,302 participants aged ≥ 21 years who were recruited at baseline during 2000-2004 were analyzed for this study. Adjusted odds ratios (ORs) were estimated in a logistic regression analysis for coronary heart disease (CHD) and cerebrovascular disease (CBD) in those with and without coexisting metabolic syndrome. Diabetic participants were excluded. RESULTS-Among those aged 35-84 years, metabolic syndrome prevalence was 43.3% in women and 32.7% in men. Elevated blood pressure (70.4%), abdominal obesity (64.6%), and low HDL cholesterol (37.2%) were highly prevalent among those with metabolic syndrome. Prevalence rates for CVD, CHD, and CBD were 12.8, 8.7, and 5.8%, respectively. After adjustment for age and sex, metabolic syndrome was associated with increased age- and sex-adjusted ORs for CVD (OR 1.7 [95% CI 1.4 -2.1]), CHD (1.7 [1.4 -2.2]), and CBD (1.7 [1.3-2.3]) compared with those without CVD, CHD, or CBD. CONCLUSION-Metabolic syndrome prevalence in the JHS is among the highest reported for population-based cohorts worldwide and is significantly associated with increased ORs for CVD, CHD, and CBD. Abdominal obesity, increased blood pressure, and low HDL cholesterol (without triglyceride elevation) are surprisingly prominent. A high prevalence of low HDL emerges as a leading contributor to metabolic syndrome among African Americans in this large African-American cohort.

Original languageEnglish (US)
Pages (from-to)3034-3043
Number of pages10
JournalApplied and environmental microbiology
Volume80
Issue number10
DOIs
StatePublished - Jan 1 2014

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African American
metabolic syndrome
cardiovascular disease
African Americans
cerebrovascular disorders
Cerebrovascular Disorders
cardiovascular diseases
Cardiovascular Diseases
Coronary Disease
odds ratio
Odds Ratio
Abdominal Obesity
high density lipoprotein cholesterol
HDL Cholesterol
blood pressure
obesity
heart
gender
blood
cohort studies

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Taylor, H., Liu, J., Wilson, G., Golden, S. H., Crook, E., Brunson, C. D., ... Sung, J. H. (2014). Distinct component profiles and high risk among african americans with metabolic syndrome. Applied and environmental microbiology, 80(10), 3034-3043. https://doi.org/10.1128/AEM.03414-13

Distinct component profiles and high risk among african americans with metabolic syndrome. / Taylor, Herman; Liu, Jiankang; Wilson, Gregory; Golden, Sherita H.; Crook, Errol; Brunson, Claude D.; Steffes, Micheal; Johnson, William D.; Sung, Jung Hye.

In: Applied and environmental microbiology, Vol. 80, No. 10, 01.01.2014, p. 3034-3043.

Research output: Contribution to journalArticle

Taylor, H, Liu, J, Wilson, G, Golden, SH, Crook, E, Brunson, CD, Steffes, M, Johnson, WD & Sung, JH 2014, 'Distinct component profiles and high risk among african americans with metabolic syndrome', Applied and environmental microbiology, vol. 80, no. 10, pp. 3034-3043. https://doi.org/10.1128/AEM.03414-13
Taylor, Herman ; Liu, Jiankang ; Wilson, Gregory ; Golden, Sherita H. ; Crook, Errol ; Brunson, Claude D. ; Steffes, Micheal ; Johnson, William D. ; Sung, Jung Hye. / Distinct component profiles and high risk among african americans with metabolic syndrome. In: Applied and environmental microbiology. 2014 ; Vol. 80, No. 10. pp. 3034-3043.
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abstract = "OBJECTIVE-Health of African Americans is seriously threatened by unremitting epidemics of diabetes and cardiovascular disease (CVD). However, the role of metabolic syndrome in the African-American population has not been investigated widely. This study examined the prevalence of metabolic syndrome and assessed its cross-sectional relationship to CVD in the Jackson Heart Study (JHS) cohort. RESEARCH DESIGNANDMETHODS-A total of 5,302 participants aged ≥ 21 years who were recruited at baseline during 2000-2004 were analyzed for this study. Adjusted odds ratios (ORs) were estimated in a logistic regression analysis for coronary heart disease (CHD) and cerebrovascular disease (CBD) in those with and without coexisting metabolic syndrome. Diabetic participants were excluded. RESULTS-Among those aged 35-84 years, metabolic syndrome prevalence was 43.3{\%} in women and 32.7{\%} in men. Elevated blood pressure (70.4{\%}), abdominal obesity (64.6{\%}), and low HDL cholesterol (37.2{\%}) were highly prevalent among those with metabolic syndrome. Prevalence rates for CVD, CHD, and CBD were 12.8, 8.7, and 5.8{\%}, respectively. After adjustment for age and sex, metabolic syndrome was associated with increased age- and sex-adjusted ORs for CVD (OR 1.7 [95{\%} CI 1.4 -2.1]), CHD (1.7 [1.4 -2.2]), and CBD (1.7 [1.3-2.3]) compared with those without CVD, CHD, or CBD. CONCLUSION-Metabolic syndrome prevalence in the JHS is among the highest reported for population-based cohorts worldwide and is significantly associated with increased ORs for CVD, CHD, and CBD. Abdominal obesity, increased blood pressure, and low HDL cholesterol (without triglyceride elevation) are surprisingly prominent. A high prevalence of low HDL emerges as a leading contributor to metabolic syndrome among African Americans in this large African-American cohort.",
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AU - Taylor, Herman

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AU - Wilson, Gregory

AU - Golden, Sherita H.

AU - Crook, Errol

AU - Brunson, Claude D.

AU - Steffes, Micheal

AU - Johnson, William D.

AU - Sung, Jung Hye

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N2 - OBJECTIVE-Health of African Americans is seriously threatened by unremitting epidemics of diabetes and cardiovascular disease (CVD). However, the role of metabolic syndrome in the African-American population has not been investigated widely. This study examined the prevalence of metabolic syndrome and assessed its cross-sectional relationship to CVD in the Jackson Heart Study (JHS) cohort. RESEARCH DESIGNANDMETHODS-A total of 5,302 participants aged ≥ 21 years who were recruited at baseline during 2000-2004 were analyzed for this study. Adjusted odds ratios (ORs) were estimated in a logistic regression analysis for coronary heart disease (CHD) and cerebrovascular disease (CBD) in those with and without coexisting metabolic syndrome. Diabetic participants were excluded. RESULTS-Among those aged 35-84 years, metabolic syndrome prevalence was 43.3% in women and 32.7% in men. Elevated blood pressure (70.4%), abdominal obesity (64.6%), and low HDL cholesterol (37.2%) were highly prevalent among those with metabolic syndrome. Prevalence rates for CVD, CHD, and CBD were 12.8, 8.7, and 5.8%, respectively. After adjustment for age and sex, metabolic syndrome was associated with increased age- and sex-adjusted ORs for CVD (OR 1.7 [95% CI 1.4 -2.1]), CHD (1.7 [1.4 -2.2]), and CBD (1.7 [1.3-2.3]) compared with those without CVD, CHD, or CBD. CONCLUSION-Metabolic syndrome prevalence in the JHS is among the highest reported for population-based cohorts worldwide and is significantly associated with increased ORs for CVD, CHD, and CBD. Abdominal obesity, increased blood pressure, and low HDL cholesterol (without triglyceride elevation) are surprisingly prominent. A high prevalence of low HDL emerges as a leading contributor to metabolic syndrome among African Americans in this large African-American cohort.

AB - OBJECTIVE-Health of African Americans is seriously threatened by unremitting epidemics of diabetes and cardiovascular disease (CVD). However, the role of metabolic syndrome in the African-American population has not been investigated widely. This study examined the prevalence of metabolic syndrome and assessed its cross-sectional relationship to CVD in the Jackson Heart Study (JHS) cohort. RESEARCH DESIGNANDMETHODS-A total of 5,302 participants aged ≥ 21 years who were recruited at baseline during 2000-2004 were analyzed for this study. Adjusted odds ratios (ORs) were estimated in a logistic regression analysis for coronary heart disease (CHD) and cerebrovascular disease (CBD) in those with and without coexisting metabolic syndrome. Diabetic participants were excluded. RESULTS-Among those aged 35-84 years, metabolic syndrome prevalence was 43.3% in women and 32.7% in men. Elevated blood pressure (70.4%), abdominal obesity (64.6%), and low HDL cholesterol (37.2%) were highly prevalent among those with metabolic syndrome. Prevalence rates for CVD, CHD, and CBD were 12.8, 8.7, and 5.8%, respectively. After adjustment for age and sex, metabolic syndrome was associated with increased age- and sex-adjusted ORs for CVD (OR 1.7 [95% CI 1.4 -2.1]), CHD (1.7 [1.4 -2.2]), and CBD (1.7 [1.3-2.3]) compared with those without CVD, CHD, or CBD. CONCLUSION-Metabolic syndrome prevalence in the JHS is among the highest reported for population-based cohorts worldwide and is significantly associated with increased ORs for CVD, CHD, and CBD. Abdominal obesity, increased blood pressure, and low HDL cholesterol (without triglyceride elevation) are surprisingly prominent. A high prevalence of low HDL emerges as a leading contributor to metabolic syndrome among African Americans in this large African-American cohort.

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