Distinct component profiles and high risk among african americans with metabolic syndrome

Herman Taylor, Jiankang Liu, Gregory Wilson, Sherita H. Golden, Errol Crook, Claude D. Brunson, Micheal Steffes, William D. Johnson, Jung Hye Sung

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - Health of African Americans is seriously threatened by unremitting epidemics of diabetes and cardiovascular disease (CVD). However, the role of metabolic syndrome in the African-American population has not been investigated widely. This study examined the prevalence of metabolic syndrome and assessed its cross-sectional relationship to CVD in the Jackson Heart Study (JHS) cohort. RESEARCH DESIGN AND METHODS - A total of 5,302 participants aged ≥21 years who were recruited at baseline during 2000-2004 were analyzed for this study. Adjusted odds ratios (ORs) were estimated in a logistic regression analysis for coronary heart disease (CHD) and cerebrovascular disease (CBD) in those with and without coexisting metabolic syndrome. Diabetic participants were excluded. RESULTS - Among those aged 35-84 years, metabolic syndrome prevalence was 43.3% in women and 32.7% in men. Elevated blood pressure (70.4%), abdominal obesity (64.6%), and low HDL cholesterol (37.2%) were highly prevalent among those with metabolic syndrome. Prevalence rates for CVD, CHD, and CBD were 12.8, 8.7, and 5.8%, respectively. After adjustment for age and sex, metabolic syndrome was associated with increased age- and sex-adjusted ORs for CVD (OR 1.7 [95% CI 1.4-2.1]), CHD (1.7 [1.4-2.2]), and CBD (1.7 [1.3-2.3]) compared with those without CVD, CHD, or CBD. CONCLUSION - Metabolic syndrome prevalence in the J HS is among the highest reported for population-based cohorts worldwide and is significantly associated with increased ORs for CVD, CHD, and CBD. Abdominal obesity, increased blood pressure, and low HDL cholesterol (without triglyceride elevation) are surprisingly prominent. A high prevalence of low HDL emerges as a leading contributor to metabolic syndrome among African Americans in this large African-American cohort.

Original languageEnglish (US)
Pages (from-to)1248-1253
Number of pages6
JournalDiabetes care
Volume31
Issue number6
DOIs
StatePublished - Jun 1 2008

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African Americans
Cerebrovascular Disorders
Cardiovascular Diseases
Coronary Disease
Odds Ratio
Abdominal Obesity
HDL Cholesterol
Hypotension
Population
Triglycerides
Cohort Studies
Research Design
Cross-Sectional Studies
Logistic Models
Regression Analysis
Blood Pressure
Health

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Taylor, H., Liu, J., Wilson, G., Golden, S. H., Crook, E., Brunson, C. D., ... Sung, J. H. (2008). Distinct component profiles and high risk among african americans with metabolic syndrome. Diabetes care, 31(6), 1248-1253. https://doi.org/10.2337/dc07-1810

Distinct component profiles and high risk among african americans with metabolic syndrome. / Taylor, Herman; Liu, Jiankang; Wilson, Gregory; Golden, Sherita H.; Crook, Errol; Brunson, Claude D.; Steffes, Micheal; Johnson, William D.; Sung, Jung Hye.

In: Diabetes care, Vol. 31, No. 6, 01.06.2008, p. 1248-1253.

Research output: Contribution to journalArticle

Taylor, H, Liu, J, Wilson, G, Golden, SH, Crook, E, Brunson, CD, Steffes, M, Johnson, WD & Sung, JH 2008, 'Distinct component profiles and high risk among african americans with metabolic syndrome', Diabetes care, vol. 31, no. 6, pp. 1248-1253. https://doi.org/10.2337/dc07-1810
Taylor H, Liu J, Wilson G, Golden SH, Crook E, Brunson CD et al. Distinct component profiles and high risk among african americans with metabolic syndrome. Diabetes care. 2008 Jun 1;31(6):1248-1253. https://doi.org/10.2337/dc07-1810
Taylor, Herman ; Liu, Jiankang ; Wilson, Gregory ; Golden, Sherita H. ; Crook, Errol ; Brunson, Claude D. ; Steffes, Micheal ; Johnson, William D. ; Sung, Jung Hye. / Distinct component profiles and high risk among african americans with metabolic syndrome. In: Diabetes care. 2008 ; Vol. 31, No. 6. pp. 1248-1253.
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abstract = "OBJECTIVE - Health of African Americans is seriously threatened by unremitting epidemics of diabetes and cardiovascular disease (CVD). However, the role of metabolic syndrome in the African-American population has not been investigated widely. This study examined the prevalence of metabolic syndrome and assessed its cross-sectional relationship to CVD in the Jackson Heart Study (JHS) cohort. RESEARCH DESIGN AND METHODS - A total of 5,302 participants aged ≥21 years who were recruited at baseline during 2000-2004 were analyzed for this study. Adjusted odds ratios (ORs) were estimated in a logistic regression analysis for coronary heart disease (CHD) and cerebrovascular disease (CBD) in those with and without coexisting metabolic syndrome. Diabetic participants were excluded. RESULTS - Among those aged 35-84 years, metabolic syndrome prevalence was 43.3{\%} in women and 32.7{\%} in men. Elevated blood pressure (70.4{\%}), abdominal obesity (64.6{\%}), and low HDL cholesterol (37.2{\%}) were highly prevalent among those with metabolic syndrome. Prevalence rates for CVD, CHD, and CBD were 12.8, 8.7, and 5.8{\%}, respectively. After adjustment for age and sex, metabolic syndrome was associated with increased age- and sex-adjusted ORs for CVD (OR 1.7 [95{\%} CI 1.4-2.1]), CHD (1.7 [1.4-2.2]), and CBD (1.7 [1.3-2.3]) compared with those without CVD, CHD, or CBD. CONCLUSION - Metabolic syndrome prevalence in the J HS is among the highest reported for population-based cohorts worldwide and is significantly associated with increased ORs for CVD, CHD, and CBD. Abdominal obesity, increased blood pressure, and low HDL cholesterol (without triglyceride elevation) are surprisingly prominent. A high prevalence of low HDL emerges as a leading contributor to metabolic syndrome among African Americans in this large African-American cohort.",
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AU - Brunson, Claude D.

AU - Steffes, Micheal

AU - Johnson, William D.

AU - Sung, Jung Hye

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N2 - OBJECTIVE - Health of African Americans is seriously threatened by unremitting epidemics of diabetes and cardiovascular disease (CVD). However, the role of metabolic syndrome in the African-American population has not been investigated widely. This study examined the prevalence of metabolic syndrome and assessed its cross-sectional relationship to CVD in the Jackson Heart Study (JHS) cohort. RESEARCH DESIGN AND METHODS - A total of 5,302 participants aged ≥21 years who were recruited at baseline during 2000-2004 were analyzed for this study. Adjusted odds ratios (ORs) were estimated in a logistic regression analysis for coronary heart disease (CHD) and cerebrovascular disease (CBD) in those with and without coexisting metabolic syndrome. Diabetic participants were excluded. RESULTS - Among those aged 35-84 years, metabolic syndrome prevalence was 43.3% in women and 32.7% in men. Elevated blood pressure (70.4%), abdominal obesity (64.6%), and low HDL cholesterol (37.2%) were highly prevalent among those with metabolic syndrome. Prevalence rates for CVD, CHD, and CBD were 12.8, 8.7, and 5.8%, respectively. After adjustment for age and sex, metabolic syndrome was associated with increased age- and sex-adjusted ORs for CVD (OR 1.7 [95% CI 1.4-2.1]), CHD (1.7 [1.4-2.2]), and CBD (1.7 [1.3-2.3]) compared with those without CVD, CHD, or CBD. CONCLUSION - Metabolic syndrome prevalence in the J HS is among the highest reported for population-based cohorts worldwide and is significantly associated with increased ORs for CVD, CHD, and CBD. Abdominal obesity, increased blood pressure, and low HDL cholesterol (without triglyceride elevation) are surprisingly prominent. A high prevalence of low HDL emerges as a leading contributor to metabolic syndrome among African Americans in this large African-American cohort.

AB - OBJECTIVE - Health of African Americans is seriously threatened by unremitting epidemics of diabetes and cardiovascular disease (CVD). However, the role of metabolic syndrome in the African-American population has not been investigated widely. This study examined the prevalence of metabolic syndrome and assessed its cross-sectional relationship to CVD in the Jackson Heart Study (JHS) cohort. RESEARCH DESIGN AND METHODS - A total of 5,302 participants aged ≥21 years who were recruited at baseline during 2000-2004 were analyzed for this study. Adjusted odds ratios (ORs) were estimated in a logistic regression analysis for coronary heart disease (CHD) and cerebrovascular disease (CBD) in those with and without coexisting metabolic syndrome. Diabetic participants were excluded. RESULTS - Among those aged 35-84 years, metabolic syndrome prevalence was 43.3% in women and 32.7% in men. Elevated blood pressure (70.4%), abdominal obesity (64.6%), and low HDL cholesterol (37.2%) were highly prevalent among those with metabolic syndrome. Prevalence rates for CVD, CHD, and CBD were 12.8, 8.7, and 5.8%, respectively. After adjustment for age and sex, metabolic syndrome was associated with increased age- and sex-adjusted ORs for CVD (OR 1.7 [95% CI 1.4-2.1]), CHD (1.7 [1.4-2.2]), and CBD (1.7 [1.3-2.3]) compared with those without CVD, CHD, or CBD. CONCLUSION - Metabolic syndrome prevalence in the J HS is among the highest reported for population-based cohorts worldwide and is significantly associated with increased ORs for CVD, CHD, and CBD. Abdominal obesity, increased blood pressure, and low HDL cholesterol (without triglyceride elevation) are surprisingly prominent. A high prevalence of low HDL emerges as a leading contributor to metabolic syndrome among African Americans in this large African-American cohort.

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