Distilling complexity to advance cardiac tissue engineering

Brenda M. Ogle; Nenad Bursac; Ibrahim Domian; Ngan F. Huang; Philippe Menasché; Charles E. Murry; Beth Pruitt; Milica Radisic; Joseph C. Wu; Sean M. Wu; Jianyi Zhang; Wolfram Hubertus Zimmermann; Gordana Vunjak-Novakovic

doi:10.1126/scitranslmed.aad2304

Distilling complexity to advance cardiac tissue engineering

Brenda M. Ogle
, Nenad Bursac
, Ibrahim Domian
, Ngan F. Huang
, Philippe Menasché
, Charles E. Murry
, Beth Pruitt
, Milica Radisic
, Joseph C. Wu
, Sean M. Wu
, Jianyi Zhang
, Wolfram Hubertus Zimmermann
, Gordana Vunjak-Novakovic

Research output: Contribution to journal › Review article › peer-review

149 Scopus citations

Abstract

The promise of cardiac tissue engineering is in the ability to recapitulate in vitro the functional aspects of a healthy heart and disease pathology as well as to design replacement muscle for clinical therapy. Parts of this promise have been realized; others have not. In a meeting of scientists in this field, five central challenges or "big questions" were articulated that, if addressed, could substantially advance the current state of the art in modeling heart disease and realizing heart repair.

Original language	English (US)
Article number	342ps13
Journal	Science Translational Medicine
Volume	8
Issue number	342
DOIs	https://doi.org/10.1126/scitranslmed.aad2304
State	Published - Jun 8 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1126/scitranslmed.aad2304

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title = "Distilling complexity to advance cardiac tissue engineering",

abstract = "The promise of cardiac tissue engineering is in the ability to recapitulate in vitro the functional aspects of a healthy heart and disease pathology as well as to design replacement muscle for clinical therapy. Parts of this promise have been realized; others have not. In a meeting of scientists in this field, five central challenges or {"}big questions{"} were articulated that, if addressed, could substantially advance the current state of the art in modeling heart disease and realizing heart repair.",

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T1 - Distilling complexity to advance cardiac tissue engineering

AU - Ogle, Brenda M.

AU - Bursac, Nenad

AU - Domian, Ibrahim

AU - Huang, Ngan F.

AU - Menasché, Philippe

AU - Murry, Charles E.

AU - Pruitt, Beth

AU - Radisic, Milica

AU - Wu, Joseph C.

AU - Wu, Sean M.

AU - Zhang, Jianyi

AU - Zimmermann, Wolfram Hubertus

AU - Vunjak-Novakovic, Gordana

PY - 2016/6/8

Y1 - 2016/6/8

N2 - The promise of cardiac tissue engineering is in the ability to recapitulate in vitro the functional aspects of a healthy heart and disease pathology as well as to design replacement muscle for clinical therapy. Parts of this promise have been realized; others have not. In a meeting of scientists in this field, five central challenges or "big questions" were articulated that, if addressed, could substantially advance the current state of the art in modeling heart disease and realizing heart repair.

AB - The promise of cardiac tissue engineering is in the ability to recapitulate in vitro the functional aspects of a healthy heart and disease pathology as well as to design replacement muscle for clinical therapy. Parts of this promise have been realized; others have not. In a meeting of scientists in this field, five central challenges or "big questions" were articulated that, if addressed, could substantially advance the current state of the art in modeling heart disease and realizing heart repair.

UR - https://www.scopus.com/pages/publications/84973882625

UR - https://www.scopus.com/pages/publications/84973882625#tab=citedBy

U2 - 10.1126/scitranslmed.aad2304

DO - 10.1126/scitranslmed.aad2304

M3 - Review article

C2 - 27280684

AN - SCOPUS:84973882625

SN - 1946-6234

VL - 8

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 342

M1 - 342ps13

ER -

Distilling complexity to advance cardiac tissue engineering

Abstract

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