Distilling complexity to advance cardiac tissue engineering

Brenda M. Ogle, Nenad Bursac, Ibrahim Domian, Ngan F. Huang, Philippe Menasché, Charles E. Murry, Beth Pruitt, Milica Radisic, Joseph C. Wu, Sean M. Wu, Jianyi Zhang, Wolfram Hubertus Zimmermann, Gordana Vunjak-Novakovic

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations


The promise of cardiac tissue engineering is in the ability to recapitulate in vitro the functional aspects of a healthy heart and disease pathology as well as to design replacement muscle for clinical therapy. Parts of this promise have been realized; others have not. In a meeting of scientists in this field, five central challenges or "big questions" were articulated that, if addressed, could substantially advance the current state of the art in modeling heart disease and realizing heart repair.

Original languageEnglish (US)
Article number342ps13
JournalScience Translational Medicine
Issue number342
StatePublished - Jun 8 2016


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