Distal acquired demyelinating symmetric neuropathy after vaccination

Karissa L. Gable, Zahra Afshari, Robert L. Sufit, Jeffrey A. Allen

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Neuropathy after vaccination is a rare event. Chronic immune-mediated polyneuropathy developing in the postvaccination period is distinctly unusual and not well described. Almost all such patients have been reported as having typical chronic inflammatory demyelinating polyneuropathy. Distal acquired demyelinating symmetric neuropathy, unlike classic chronic inflammatory demyelinating polyneuropathy, is characterized by distally predominant sensory symptoms with no or mild distal weakness. We describe the clinical, laboratory, and neurophysiological findings of 2 patients who developed distal acquired demyelinating symmetric neuropathy after vaccination. Immunomodulatory therapy led to clinical improvement in both cases. The literature is reviewed with attention to the clinical features of chronic immune-mediated neuropathies that follow vaccination.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalJournal of Clinical Neuromuscular Disease
Issue number3
StatePublished - Mar 2013


  • CIDP
  • autoimmune
  • demyelinating
  • distal
  • neuropathy
  • vaccination


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