Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for severe aplastic anemia

Neil J. Rawlinson; Bonita Fung; Thomas G. Gross; Amanda M. Termuhlen; Micah Skeens; Amy Garee; Sandeep Soni; Daniel Pietryga; Rajinder P.S. Bajwa

doi:10.1097/MPH.0b013e3182050a4f

Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for severe aplastic anemia

Neil J. Rawlinson, Bonita Fung, Thomas G. Gross, Amanda M. Termuhlen, Micah Skeens, Amy Garee, Sandeep Soni, Daniel Pietryga, Rajinder P.S. Bajwa

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Matched sibling donor hematopoietic stem cell transplantation is the standard of care for severe aplastic anemia, with an overall survival of 80% to 90%. Only 60% to 70% of patients respond to treatment with immunosuppressive therapy. The main life threatening complications are infections, graft failure, and graft versus host disease. A 10-year-old patient with severe aplastic anemia underwent matched sibling donor hematopoietic stem cell transplantation, but developed sudden onset of fatal multiorgan failure on day +12. The cause of death was found only after autopsy.

Original language	English (US)
Pages (from-to)	235-237
Number of pages	3
Journal	Journal of pediatric hematology/oncology
Volume	33
Issue number	3
DOIs	https://doi.org/10.1097/MPH.0b013e3182050a4f
State	Published - Apr 2011
Externally published	Yes

Keywords

aplastic anemia
fungal infection
hematopoietic stem cell transplantation
multiorgan failure

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10.1097/MPH.0b013e3182050a4f

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Rawlinson, N. J., Fung, B., Gross, T. G., Termuhlen, A. M., Skeens, M., Garee, A., Soni, S., Pietryga, D., & Bajwa, R. P. S. (2011). Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for severe aplastic anemia. Journal of pediatric hematology/oncology, 33(3), 235-237. https://doi.org/10.1097/MPH.0b013e3182050a4f

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abstract = "Matched sibling donor hematopoietic stem cell transplantation is the standard of care for severe aplastic anemia, with an overall survival of 80% to 90%. Only 60% to 70% of patients respond to treatment with immunosuppressive therapy. The main life threatening complications are infections, graft failure, and graft versus host disease. A 10-year-old patient with severe aplastic anemia underwent matched sibling donor hematopoietic stem cell transplantation, but developed sudden onset of fatal multiorgan failure on day +12. The cause of death was found only after autopsy.",

keywords = "aplastic anemia, fungal infection, hematopoietic stem cell transplantation, multiorgan failure",

author = "Rawlinson, {Neil J.} and Bonita Fung and Gross, {Thomas G.} and Termuhlen, {Amanda M.} and Micah Skeens and Amy Garee and Sandeep Soni and Daniel Pietryga and Bajwa, {Rajinder P.S.}",

year = "2011",

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AU - Rawlinson, Neil J.

AU - Fung, Bonita

AU - Gross, Thomas G.

AU - Termuhlen, Amanda M.

AU - Skeens, Micah

AU - Garee, Amy

AU - Soni, Sandeep

AU - Pietryga, Daniel

AU - Bajwa, Rajinder P.S.

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AB - Matched sibling donor hematopoietic stem cell transplantation is the standard of care for severe aplastic anemia, with an overall survival of 80% to 90%. Only 60% to 70% of patients respond to treatment with immunosuppressive therapy. The main life threatening complications are infections, graft failure, and graft versus host disease. A 10-year-old patient with severe aplastic anemia underwent matched sibling donor hematopoietic stem cell transplantation, but developed sudden onset of fatal multiorgan failure on day +12. The cause of death was found only after autopsy.

KW - aplastic anemia

KW - fungal infection

KW - hematopoietic stem cell transplantation

KW - multiorgan failure

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Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for severe aplastic anemia

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