Disseminated intracranial Ewing's sarcoma in an adult: A rare and difficult diagnosis

Emil Lou, Ashley L. Sumrall, Thomas J. Cummings, David N. Korones, Susan A. Weaver, Katherine B. Peters

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The Ewing sarcoma family of tumors comprises a rare class of cancers of mesenchymal origin. Cases of Ewing's sarcoma in the central nervous system - specifically, intracranial Ewing's - are extremely rare. Almost all reported cases have occurred in children. However, this rare presentation can also occur in the adult population. It is important to distinguish these tumors from primitive neuroectodermal tumors at the time of diagnosis. Testing for EWSR1(22q12) gene rearrangement using fluorescence in situ hybridization is a useful tool for making the distinction between these 2 similar but distinct entities. We present here the case of a middle-aged male patient with intracranial Ewing's sarcoma, and discuss diagnostic challenges and potential new treatment approaches for this rare disease.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalCase Reports in Oncology
Volume5
Issue number2
DOIs
StatePublished - May 2012

Keywords

  • Ewing's sarcoma, intracranial
  • Magnetic resonance imaging
  • Primitive neuroectodermal tumor

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