Abstract
Subtle semantic deficits can be observed in Alzheimer's disease (AD) patients even in the early stages of the illness. In this work, we tested the hypothesis that the semantic control network is deregulated in mild AD patients. We assessed the integrity of the semantic control system using resting-state functional magnetic resonance imaging in a cohort of patients with mild AD (n = 38; mean mini-mental state examination = 20.5) and in a group of age-matched healthy controls (n = 19). Voxel-wise analysis spatially constrained in the left fronto-temporal semantic control network identified two regions with altered functional connectivity (FC) in AD patients, specifically in the pars opercularis (POp, BA44) and in the posterior middle temporal gyrus (pMTG, BA21). Using whole-brain seed-based analysis, we demonstrated that these two regions have altered FC even beyond the semantic control network. In particular, the pMTG displayed a wide-distributed pattern of lower connectivity to several brain regions involved in language-semantic processing, along with a possibly compensatory higher connectivity to the Wernicke's area. We conclude that in mild AD brain regions belonging to the semantic control network are abnormally connected not only within the network, but also to other areas known to be critical for language processing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 38-48 |
| Number of pages | 11 |
| Journal | Neuroscience |
| Volume | 371 |
| DOIs | |
| State | Published - Feb 10 2018 |
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Keywords
- Alzheimer's disease
- inferior frontal gyrus
- posterior middle temporal gyrus
- resting-state fMRI
- semantic control network
- voxel-wise functional connectivity
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
Cite this
Disruption of Semantic Network in Mild Alzheimer's Disease Revealed by Resting-State fMRI. / Mascali, Daniele; DiNuzzo, Mauro; Serra, Laura; Mangia, Silvia; Maraviglia, Bruno; Bozzali, Marco; Giove, Federico.
In: Neuroscience, Vol. 371, 10.02.2018, p. 38-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disruption of Semantic Network in Mild Alzheimer's Disease Revealed by Resting-State fMRI
AU - Mascali, Daniele
AU - DiNuzzo, Mauro
AU - Serra, Laura
AU - Mangia, Silvia
AU - Maraviglia, Bruno
AU - Bozzali, Marco
AU - Giove, Federico
PY - 2018/2/10
Y1 - 2018/2/10
N2 - Subtle semantic deficits can be observed in Alzheimer's disease (AD) patients even in the early stages of the illness. In this work, we tested the hypothesis that the semantic control network is deregulated in mild AD patients. We assessed the integrity of the semantic control system using resting-state functional magnetic resonance imaging in a cohort of patients with mild AD (n = 38; mean mini-mental state examination = 20.5) and in a group of age-matched healthy controls (n = 19). Voxel-wise analysis spatially constrained in the left fronto-temporal semantic control network identified two regions with altered functional connectivity (FC) in AD patients, specifically in the pars opercularis (POp, BA44) and in the posterior middle temporal gyrus (pMTG, BA21). Using whole-brain seed-based analysis, we demonstrated that these two regions have altered FC even beyond the semantic control network. In particular, the pMTG displayed a wide-distributed pattern of lower connectivity to several brain regions involved in language-semantic processing, along with a possibly compensatory higher connectivity to the Wernicke's area. We conclude that in mild AD brain regions belonging to the semantic control network are abnormally connected not only within the network, but also to other areas known to be critical for language processing.
AB - Subtle semantic deficits can be observed in Alzheimer's disease (AD) patients even in the early stages of the illness. In this work, we tested the hypothesis that the semantic control network is deregulated in mild AD patients. We assessed the integrity of the semantic control system using resting-state functional magnetic resonance imaging in a cohort of patients with mild AD (n = 38; mean mini-mental state examination = 20.5) and in a group of age-matched healthy controls (n = 19). Voxel-wise analysis spatially constrained in the left fronto-temporal semantic control network identified two regions with altered functional connectivity (FC) in AD patients, specifically in the pars opercularis (POp, BA44) and in the posterior middle temporal gyrus (pMTG, BA21). Using whole-brain seed-based analysis, we demonstrated that these two regions have altered FC even beyond the semantic control network. In particular, the pMTG displayed a wide-distributed pattern of lower connectivity to several brain regions involved in language-semantic processing, along with a possibly compensatory higher connectivity to the Wernicke's area. We conclude that in mild AD brain regions belonging to the semantic control network are abnormally connected not only within the network, but also to other areas known to be critical for language processing.
KW - Alzheimer's disease
KW - inferior frontal gyrus
KW - posterior middle temporal gyrus
KW - resting-state fMRI
KW - semantic control network
KW - voxel-wise functional connectivity
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UR - http://www.scopus.com/inward/citedby.url?scp=85038008344&partnerID=8YFLogxK
U2 - 10.1016/j.neuroscience.2017.11.030
DO - 10.1016/j.neuroscience.2017.11.030
M3 - Article
VL - 371
SP - 38
EP - 48
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
ER -