Disrupting the medial prefrontal cortex with designer receptors exclusively activated by designer drug alters hippocampal sharp-wave ripples and their associated cognitive processes

Research output: Contribution to journalArticlepeer-review

Abstract

The hippocampus and medial prefrontal cortex (mPFC) interact during a myriad of cognitive processes including decision-making and long-term memory consolidation. Exactly how the mPFC and hippocampus interact during goal-directed decision-making remains to be fully elucidated. During periods of rest, bursts of high-frequency oscillations, termed sharp-wave ripple (SWR), appear in the local field potential. Impairing SWRs on the maze or during post-learning rest can interfere with memory-guided decision-making and memory consolidation. We hypothesize that the hippocampus and mPFC bidirectionally interact during SWRs to support memory consolidation and decision-making. Rats were trained on the neuroeconomic spatial decision-making task, Restaurant Row, to make serial stay-skip decisions where the amount of effort (delay to reward) varied upon entry to each restaurant. Hippocampal cells and SWRs were recorded in rats with the mPFC transduced with inhibitory DREADDs. We found that disrupting the mPFC impaired consolidating SWRs in the hippocampus. Hippocampal SWR rates depended on the internalized value of the reward (derived from individual flavor preferences), a parameter important in decision-making, and disrupting the mPFC changed this relationship. Additionally, we found a dissociation between SWRs that occurred while rats were on the maze dependent upon whether those SWRs occurred while the rat was anticipating food reward or during post-reward consumption.

Original languageEnglish (US)
Pages (from-to)1051-1067
Number of pages17
JournalHippocampus
Volume31
Issue number10
Early online dateJun 9 2021
DOIs
StatePublished - Oct 2021

Bibliographical note

Funding Information:
The authors would like to thank Dr. Bryan Roth, Dr. Daniel Urban and the UNC Vector Core for help with viruses, DREADDs set‐up, and troubleshooting. Technical assistance was provided by Kelsey Seeland, Christopher Boldt, and Ayaka Sheehan. Financial support for this work was provided by NIDA grant DA030672 (ADR), NIMH grant MH080318 (ADR), as well as a diversity supplement NIDA DA030672S1 (BJS), funding from the Society for Neuroscience Scholars Program (BJS), and an NIH NRSA fellowship DA038392 (BJS).

Funding Information:
The authors would like to thank Dr. Bryan Roth, Dr. Daniel Urban and the UNC Vector Core for help with viruses, DREADDs set-up, and troubleshooting. Technical assistance was provided by Kelsey Seeland, Christopher Boldt, and Ayaka Sheehan. Financial support for this work was provided by NIDA grant DA030672 (ADR), NIMH grant MH080318 (ADR), as well as a diversity supplement NIDA DA030672S1 (BJS), funding from the Society for Neuroscience Scholars Program (BJS), and an NIH NRSA fellowship DA038392 (BJS).

Publisher Copyright:
© 2021 Wiley Periodicals LLC.

Keywords

  • Restaurant Row
  • consolidation
  • decision-making
  • foraging
  • neuroeconomic
  • spatial navigation

PubMed: MeSH publication types

  • Journal Article

Fingerprint

Dive into the research topics of 'Disrupting the medial prefrontal cortex with designer receptors exclusively activated by designer drug alters hippocampal sharp-wave ripples and their associated cognitive processes'. Together they form a unique fingerprint.

Cite this