Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction

Keyphrases

• Liver 100%
• Gene-deficient Mice 100%
• Oxidative Metabolism 100%
• S-adenosylmethionine 100%
• Methionine Restriction 100%
• Glycine N-methyltransferase 100%
• Knock-in Mouse Model 50%
• Gluconeogenesis 30%
• Cycle Flux 30%
• Citric Acid Cycle 30%
• Oxidative Phosphorylation (OXPHOS) 20%
• Liver Steatosis 20%
• Nutrient Pools 10%
• Genotype 10%
• Metabolomics 10%
• Dysregulated 10%
• Non-alcoholic Fatty Liver Disease (NAFLD) 10%
• Null Mice 10%
• Methionine 10%
• Lipogenesis 10%
• Glycine 10%
• Folic Acid 10%
• Lipid Accumulation 10%
• Nutrient Flux 10%
• Mitochondrial Oxidative Phosphorylation 10%
• Cytochrome c Oxidase 10%
• One-carbon Metabolism 10%
• One-carbon 10%
• Donor Availability 10%
• Pool Size 10%
• Respiratory Function 10%
• Restricted Diet 10%
• 13C Metabolic Flux Analysis 10%
• Triacylglycerides 10%
• Dietary Methionine 10%
• Metabolic Implications 10%
• High-resolution Respirometry 10%
• Folate Cycle 10%
• Fold Increase 10%
• Carbon Donors 10%

Medicine and Dentistry

• Aerobic Metabolism 100%
• Methionine 100%
• S-Adenosyl Methionine 100%
• Methyltransferase 100%
• Knockout Mouse 60%
• Gluconeogenesis 30%
• Citric Acid Cycle 30%
• Oxidative Phosphorylation 30%
• Fatty Liver 20%
• Folic Acid 20%
• Metabolomics 10%
• Diet Restriction 10%
• Nonalcoholic Fatty Liver 10%
• Respiratory Physiology 10%
• Nutritional Deficiency 10%
• Serine 10%
• Lipid Storage 10%
• Carbon 13 10%
• Cytochrome C Oxidase 10%
• Metabolic Flux Analysis 10%
• Carbon Metabolism 10%
• Respirometry 10%
• Lipogenesis 10%

Biochemistry, Genetics and Molecular Biology

• Aerobic Metabolism 100%
• Methyltransferase 100%
• S-Adenosyl Methionine 100%
• Methionine 100%
• Knockout Mouse 60%
• Citric Acid Cycle 30%
• Gluconeogenesis 30%
• Oxidative Phosphorylation 30%
• Folic Acid 20%
• Genotyping 10%
• Metabolic Flux Analysis 10%
• Lipogenesis 10%
• Respiratory Function 10%
• Metabolomics 10%
• Lipid Storage 10%
• Carbon Metabolism 10%
• Cytochrome C Oxidase 10%
• Serine 10%