Lantadene A (LA) administered orally to guinea pigs elicited cholestasis. LA could not be detected in liver, bile, gall bladder, blood and urine. LA and its biotransformation product reduced lantadene A (RLA) could be detected in caecum, large intestine, and faeces. In vitro incubation of LA with liver homogenates under aerobic and anaerobic conditions did not elicit its biotransformation to RLA. On the other hand, in vitro incubation of LA with guinea pig caecal and large intestinal contents under anaerobic conditions elicited conversion of LA to RLA. This is the first report of the biotransformation of LA in the animal system. Copyright (C) 1999 Elsevier Science Ireland Ltd.
Bibliographical noteFunding Information:
This work was supported by a research grant from the Department of Science and Technology, New Delhi. S.S. thanks the DST for the award of a junior research fellowship. The authors thank Dr O.S. Tomer, Director of the institute for the facilities and Dr B. Singh the Scientist-in-Charge for helpful discussions.
- Lantadene A