Disposition of lantadene A, the pentacyclic triterpenoid hepatotoxin, orally administered to guinea pigs

Sarita Sharma, Om P. Sharma, Rajinder K. Dawra, Tej K. Bhat

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Lantadene A (LA) administered orally to guinea pigs elicited cholestasis. LA could not be detected in liver, bile, gall bladder, blood and urine. LA and its biotransformation product reduced lantadene A (RLA) could be detected in caecum, large intestine, and faeces. In vitro incubation of LA with liver homogenates under aerobic and anaerobic conditions did not elicit its biotransformation to RLA. On the other hand, in vitro incubation of LA with guinea pig caecal and large intestinal contents under anaerobic conditions elicited conversion of LA to RLA. This is the first report of the biotransformation of LA in the animal system. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalToxicology Letters
Volume105
Issue number1
DOIs
StatePublished - Mar 8 1999

Bibliographical note

Funding Information:
This work was supported by a research grant from the Department of Science and Technology, New Delhi. S.S. thanks the DST for the award of a junior research fellowship. The authors thank Dr O.S. Tomer, Director of the institute for the facilities and Dr B. Singh the Scientist-in-Charge for helpful discussions.

Keywords

  • Biotransformation
  • Disposition
  • Hepatotoxin
  • Lantadene A

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