Dishevelled: A masterful conductor of complex Wnt signals

Monica Sharma; Isabel Castro-Piedras; Glenn E. Simmons; Kevin Pruitt

doi:10.1016/j.cellsig.2018.03.004

Dishevelled: A masterful conductor of complex Wnt signals

Monica Sharma, Isabel Castro-Piedras, Glenn E. Simmons, Kevin Pruitt

Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

144 Scopus citations

Abstract

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1–3]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic development in Drosophila [4]. Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5–10]. Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. This review will revisit seminal discoveries and also summarize recent advances in characterizing the role of Dishevelled in both normal and pathophysiological settings.

Original language	English (US)
Pages (from-to)	52-64
Number of pages	13
Journal	Cellular Signalling
Volume	47
DOIs	https://doi.org/10.1016/j.cellsig.2018.03.004
State	Published - Jul 2018

Bibliographical note

Funding Information:
This work was supported by the National Institute of Health [CA155223 to K.P.] and a Cancer Prevention and Research Institute of Texas (CPRIT) Award [RR140008 to K.P.].

Funding Information:
This work was supported by the National Institute of Health [ CA155223 to K.P.] and a Cancer Prevention and Research Institute of Texas (CPRIT) Award [ RR140008 to K.P.].

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

Cancer
Development
Disease
Dishevelled
Wnt
β-catenin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cellsig.2018.03.004

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317740

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abstract = "The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1–3]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic development in Drosophila [4]. Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5–10]. Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. This review will revisit seminal discoveries and also summarize recent advances in characterizing the role of Dishevelled in both normal and pathophysiological settings.",

keywords = "Cancer, Development, Disease, Dishevelled, Wnt, β-catenin",

author = "Monica Sharma and Isabel Castro-Piedras and Simmons, {Glenn E.} and Kevin Pruitt",

note = "Funding Information: This work was supported by the National Institute of Health [CA155223 to K.P.] and a Cancer Prevention and Research Institute of Texas (CPRIT) Award [RR140008 to K.P.]. Funding Information: This work was supported by the National Institute of Health [ CA155223 to K.P.] and a Cancer Prevention and Research Institute of Texas (CPRIT) Award [ RR140008 to K.P.]. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

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doi = "10.1016/j.cellsig.2018.03.004",

language = "English (US)",

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AU - Sharma, Monica

AU - Castro-Piedras, Isabel

AU - Simmons, Glenn E.

AU - Pruitt, Kevin

N1 - Funding Information: This work was supported by the National Institute of Health [CA155223 to K.P.] and a Cancer Prevention and Research Institute of Texas (CPRIT) Award [RR140008 to K.P.]. Funding Information: This work was supported by the National Institute of Health [ CA155223 to K.P.] and a Cancer Prevention and Research Institute of Texas (CPRIT) Award [ RR140008 to K.P.]. Publisher Copyright: © 2018 Elsevier Inc.

PY - 2018/7

Y1 - 2018/7

N2 - The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1–3]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic development in Drosophila [4]. Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5–10]. Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. This review will revisit seminal discoveries and also summarize recent advances in characterizing the role of Dishevelled in both normal and pathophysiological settings.

AB - The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1–3]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic development in Drosophila [4]. Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5–10]. Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. This review will revisit seminal discoveries and also summarize recent advances in characterizing the role of Dishevelled in both normal and pathophysiological settings.

KW - Cancer

KW - Development

KW - Disease

KW - Dishevelled

KW - Wnt

KW - β-catenin

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DO - 10.1016/j.cellsig.2018.03.004

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AN - SCOPUS:85045005611

SN - 0898-6568

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SP - 52

EP - 64

JO - Cellular Signalling

JF - Cellular Signalling

ER -

Dishevelled: A masterful conductor of complex Wnt signals

Abstract

Bibliographical note

Keywords

UN SDGs

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