Dishevelled: A masterful conductor of complex Wnt signals

Monica Sharma, Isabel Castro-Piedras, Glenn E. Simmons, Kevin Pruitt

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1–3]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic development in Drosophila [4]. Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5–10]. Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. This review will revisit seminal discoveries and also summarize recent advances in characterizing the role of Dishevelled in both normal and pathophysiological settings.

Original languageEnglish (US)
Pages (from-to)52-64
Number of pages13
JournalCellular Signalling
Volume47
DOIs
StatePublished - Jul 2018

Bibliographical note

Funding Information:
This work was supported by the National Institute of Health [CA155223 to K.P.] and a Cancer Prevention and Research Institute of Texas (CPRIT) Award [RR140008 to K.P.].

Funding Information:
This work was supported by the National Institute of Health [ CA155223 to K.P.] and a Cancer Prevention and Research Institute of Texas (CPRIT) Award [ RR140008 to K.P.].

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

  • Cancer
  • Development
  • Disease
  • Dishevelled
  • Wnt
  • β-catenin

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