Discrete changes in brain calcium with morphine analgesia, tolerance-dependence, and abstinence

R. Adron Harris, Hiroaki Yamamoto, Horace H. Loh, E. Leong Way

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Subcellular localization of 45Ca++ in brain was determined after intracerebroventricular injection of the isotope in mice. Acute morphine injection selectively depleted 45Ca++ from synaptic vesicles while chronic morphine treatment increased the 45Ca++ in vesicular fractions. The elevated vesicular 45Ca++ found in tolerant-dependent animals rapidly declined during naloxone precipitated abstinence. These effects of morphine on brain Ca++ localization are discussed in terms of their possible relationship to neurotransmitter release and tolerance and dependence development.

Original languageEnglish (US)
Pages (from-to)501-505
Number of pages5
JournalLife Sciences
Volume20
Issue number3
DOIs
StatePublished - Feb 1 1977

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