Subcellular localization of 45Ca++ in brain was determined after intracerebroventricular injection of the isotope in mice. Acute morphine injection selectively depleted 45Ca++ from synaptic vesicles while chronic morphine treatment increased the 45Ca++ in vesicular fractions. The elevated vesicular 45Ca++ found in tolerant-dependent animals rapidly declined during naloxone precipitated abstinence. These effects of morphine on brain Ca++ localization are discussed in terms of their possible relationship to neurotransmitter release and tolerance and dependence development.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Feb 1 1977|