Discrepancy in vancomycin AUC/MIC ratio targeted attainment based upon the susceptibility testing in Staphylococcus aureus

Seenae Eum, Robert L. Bergsbaken, Craig L. Harvey, J. Bryan Warren, John C. Rotschafer

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

This study demonstrated a statistically significant difference in vancomycin minimum inhibitory concentration (MIC) for Staphylococcus aureus between a common automated system (Vitek 2) and the E-test method in patients with S. aureus bloodstream infections. At an area under the serum concentration time curve (AUC) threshold of 400 mg·h/L, we would have reached the current Infectious Diseases Society of America (IDSA)/American Society of Health System Pharmacists (ASHP)/Society of Infectious Diseases Pharmacists (SIDP) guideline suggested AUC/MIC target in almost 100% of patients while using the Vitek 2 MIC data; however, we could only generate 40% target attainment while using E-test MIC data (p < 0.0001). An AUC of 450 mg·h/L or greater was required to achieve 100% target attainment using either Vitek 2 or E-test MIC results.

Original languageEnglish (US)
Article number34
JournalAntibiotics
Volume5
Issue number4
DOIs
StatePublished - Dec 2016

Keywords

  • MIC
  • Staphylococcus aureus
  • Susceptibility testing
  • Vancomycin

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