TY - JOUR
T1 - Discovery of biological networks from diverse functional genomic data
AU - Myers, Chad L.
AU - Robson, Drew
AU - Wible, Adam
AU - Hibbs, Matthew A.
AU - Chiriac, Camelia
AU - Theesfeld, Chandra L.
AU - Dolinski, Kara
AU - Troyanskaya, Olga G.
PY - 2005/12/19
Y1 - 2005/12/19
N2 - We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.
AB - We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.
UR - http://www.scopus.com/inward/record.url?scp=33745113181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745113181&partnerID=8YFLogxK
U2 - 10.1186/gb-2005-6-13-r114
DO - 10.1186/gb-2005-6-13-r114
M3 - Article
C2 - 16420673
AN - SCOPUS:33745113181
SN - 1474-760X
VL - 6
JO - Genome biology
JF - Genome biology
IS - 13
M1 - R114
ER -