Discovery, characterization, and pharmaceutical applications of two loratadine–oxalic acid cocrystals

Zhengxuan Liang, Hongbo Chen, Chenguang Wang, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review


Loratadine (Lor) is an antihistamine drug commonly used to relieve the symptoms of allergy. It has high permeability but low solubility under physiological conditions. To overcome the problem of low solubility, we synthesized and characterized two Loratadine multi-component crystalline phases with oxalic acid (Oxa), i.e., a 1:1 Lor-Oxa conjugate acid-base (CAB) cocrystal (Lor-Oxa CAB) and a 2:1 Lor-Oxa cocrystal monohydrate (Lor-Oxa hydrate). Both cocrystals exhibited an enhanced solubility and intrinsic dissolution rate (IDR) compared to Lor and adequate physical stability. The intrinsic dissolution rate of Lor-Oxa CAB is 95 times that of Lor, which makes it a promising candidate for tablet formulation development.

Original languageEnglish (US)
Article number996
Pages (from-to)1-15
Number of pages15
Issue number11
StatePublished - Nov 2020

Bibliographical note

Funding Information:
Acknowledgments: We thank the Minnesota Supercomputing Institute (MSI) at the University of Minnesota for providing the resources that contributed to the research results reported within this paper (http://www.msi. The Bruker-AXS D8 Venture diffractometer was purchased through a grant from NSF/MRI (#1229400) and the University of Minnesota.


  • Cocrystal
  • Compression
  • Intrinsic dissolution rate
  • Loratadine
  • Solubility

Fingerprint Dive into the research topics of 'Discovery, characterization, and pharmaceutical applications of two loratadine–oxalic acid cocrystals'. Together they form a unique fingerprint.

Cite this