Discovery and development of anti-angiogenic peptides: A structural link

Ruud P.M. Dings, Irina Nesmelova, Arjan W. Griffioen, Kevin H Mayo

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Cancer is a disease promoted by excess angiogenesis. Interference with this process poses an attractive approach to controling aberrant tumor growth, a hypothesis first proposed in the early 1970s that led to world-wide focus on identifying and developing angiogenesis inhibitors, which currently number in the hundreds. This review surveys the discovery and development of anti-angiogenic protein fragments and peptides, with a slant towards understanding their structure-function relationships to aid in the design of better therapeutic agents.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalAngiogenesis
Volume6
Issue number2
DOIs
StatePublished - 2003

Bibliographical note

Funding Information:
This research was supported by grants from the Dutch Cancer Society (to A.W. Griffioen), the Department of Defense DA/DAMD 17-99-1-9564 (to K.H. Mayo) and the National Institutes of Health R01 CA-96090 (to K.H. Mayo).

Keywords

  • Angiogenesis inhibition
  • Angiostatic peptides
  • Angiostatic proteins
  • Designer peptides and review

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