Discovering lactic acid bacteria by genomics

Todd Klaenhammer, Eric Altermann, Fabrizio Arigoni, Alexander Bolotin, Fred Breidt, Jeffrey Broadbent, Raul Cano, Stephane Chaillou, Josef Deutscher, Mike Gasson, Maarten van de Guchte, Jean Guzzo, Axel Hartke, Trevor Hawkins, Pascal Hols, Robert Hutkins, Michiel Kleerebezem, Jan Kok, Oscar Kuipers, Mark LubbersEmmanuelle Maguin, Larry McKay, David Mills, Arjen Nauta, Ross Overbeek, Herman Pel, David Pridmore, Milton Saier, Douwe van Sinderen, Alexei Sorokin, James Steele, Daniel O'Sullivan, Willem de Vos, Bart Weimer, Monique Zagorec, Roland Siezen

Research output: Contribution to journalArticlepeer-review

186 Scopus citations

Abstract

This review summarizes a collection of lactic acid bacteria that are now undergoing genomic sequencing and analysis. Summaries are presented on twenty different species, with each overview discussing the organisms fundamental and practical significance, environmental habitat, and its role in fermentation, bioprocessing, or probiotics. For those projects where genome sequence data were available by March 2002, summaries include a listing of key statistics and interesting genomic features. These efforts will revolutionize our molecular view of Gram-positive bacteria, as up to 15 genomes from the low GC content lactic acid bacteria are expected to be available in the public domain by the end of 2003. Our collective view of the lactic acid bacteria will be fundamentally changed as we rediscover the relationships and capabilities of these organisms through genomics.

Original languageEnglish (US)
Pages (from-to)29-58
Number of pages30
JournalAntonie van Leeuwenhoek, International Journal of General and Molecular Microbiology
Volume82
Issue number1-4
DOIs
StatePublished - Aug 2002

Bibliographical note

Funding Information:
We acknowledge the valuable contributes of Michael Collett, Christopher Pillidge, and Marie-Laure De-labre, and the financial support of our sponsors Vi-aLactia BioSciences NZ Ltd, the New Zealand Foundation for Research Science and Technology, and the Marsden Fund of the Royal Society of New Zealand.

Funding Information:
This project was supported by Dairy Management, Inc, the Southeast Dairy Foods Research Center, the California Dairy Foods Research Center, the Environmental Biotechnology Institute and Rhodia, Inc. The efforts of Eric Altermann, Mike Russell, A. Hamrick, T. Cox, and D. Doherty are gratefully acknowledged.

Funding Information:
The Joint Genome Institute of the US Department of Energy and the Lactic Acid Bacteria Genome Consortium is supporting this sequencing project. The efforts of R. Barrangou, E. Altermann, W. M. Russell, T. Hawkins, S. Stilwagen, P. Richardson, and K. Kadner are gratefully acknowledged. Additional support was provided by Dairy Management, Inc, the Southeast Dairy Foods Research Center and Rhodia, Inc.

Funding Information:
This project was supported by Dairy Management, Inc. through the Wisconsin Center for Dairy Research and the Western Dairy Center, College of Agricultural and Life Sciences and Chr. Hansen, Inc. Fred Blattner and George F. Mayhew from the Genome Center of Wisconsin are thanked for their assistance with genome assembly and annotation.

Funding Information:
This project was financed by the Institut National de la Recherche Agronomique (INRA).

Funding Information:
We acknowledge the participation of Yanick Auf-fray, Alain Mazé, Gregory Boël, Ivan Mijakovic, Jean-Christophe Giard, Jean Marie Laplace, Abdel-lah Benachour, Alain Rincé, Vianney Pichereau and the financial aide from the INRA, the Ministère de la Recherche and the Conseil Régionale de Basse-Normandie.

Funding Information:
This project was supported by the US Department of Energy–Joint Genome Institute, the American Vineyard Foundation, and the California Competitive Grants Program for Research in Viticulture and Enology. The efforts of C. M. Joseph, K. Ranstiou, T. Hawkins, S. Stilwagen, P. Richardson, and K. Kadner are gratefully acknowledged.

Keywords

  • Bifidobacterium
  • Brevibacterium
  • Food
  • Genomics
  • Gram-positive bacteria
  • Health
  • Lactic acid bacteria
  • Lactobacillus
  • Lactococcus
  • Leuconostoc
  • Oenococcus
  • Pediococcus
  • Propionibacterium
  • Streptococcus

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