Discordance between traditional pathologic and energy metabolic changes in very early Alzheimer's disease

Satoshi Minoshima, Donna J. Cross, Norman L. Foster, Thomas R. Henry, David E. Kuhl

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

These results suggest that neither the loss of entorhinal efferents nor cholinergic deficit explains all the metabolic features seen in very early AD. Given recent immunohistological evidence of massive glutamatergic synaptic alteration in early AD cortex and insights into neuronal and glial mechanisms of glucose metabolism, very early metabolic changes in AD probably reflect a significant impairment of glycolytic activities in the cortico-cortical glutamatergic systems in a preclinical stage of the disease. However, the exact mechanisms of such impairment in these neurons are yet to be determined.

Original languageEnglish (US)
Pages (from-to)350-352
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume893
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Dive into the research topics of 'Discordance between traditional pathologic and energy metabolic changes in very early Alzheimer's disease'. Together they form a unique fingerprint.

Cite this