Direct sequencing of the human microbiome readily reveals community differences

Justin Kuczynski; Elizabeth K. Costello; Diana R. Nemergut; Jesse Zaneveld; Christian L. Lauber; Dan Knights; Omry Koren; Noah Fierer; Scott T. Kelley; Ruth E. Ley; Jeffrey I. Gordon; Rob Knight

doi:10.1186/gb-2010-11-5-210

Direct sequencing of the human microbiome readily reveals community differences

Justin Kuczynski
, Elizabeth K. Costello
, Diana R. Nemergut
, Jesse Zaneveld
, Christian L. Lauber
, Dan Knights
, Omry Koren
, Noah Fierer
, Scott T. Kelley
, Ruth E. Ley
, Jeffrey I. Gordon
, Rob Knight

Biotechnology Institute

Research output: Contribution to journal › Review article › peer-review

137 Scopus citations

Abstract

Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.

Original language	English (US)
Article number	210
Journal	Genome biology
Volume	11
Issue number	5
DOIs	https://doi.org/10.1186/gb-2010-11-5-210
State	Published - May 5 2010

Bibliographical note

Funding Information:
We thank the Crohn’s and Colitis Foundation of America, the Bill and Melinda Gates Foundation, the HHMI and the NIH for support of work by the authors cited in this review.

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10.1186/gb-2010-11-5-210

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title = "Direct sequencing of the human microbiome readily reveals community differences",

abstract = "Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.",

author = "Justin Kuczynski and Costello, \{Elizabeth K.\} and Nemergut, \{Diana R.\} and Jesse Zaneveld and Lauber, \{Christian L.\} and Dan Knights and Omry Koren and Noah Fierer and Kelley, \{Scott T.\} and Ley, \{Ruth E.\} and Gordon, \{Jeffrey I.\} and Rob Knight",

note = "Funding Information: We thank the Crohn{\textquoteright}s and Colitis Foundation of America, the Bill and Melinda Gates Foundation, the HHMI and the NIH for support of work by the authors cited in this review.",

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month = may,

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AU - Kuczynski, Justin

AU - Costello, Elizabeth K.

AU - Nemergut, Diana R.

AU - Zaneveld, Jesse

AU - Lauber, Christian L.

AU - Knights, Dan

AU - Koren, Omry

AU - Fierer, Noah

AU - Kelley, Scott T.

AU - Ley, Ruth E.

AU - Gordon, Jeffrey I.

AU - Knight, Rob

N1 - Funding Information: We thank the Crohn’s and Colitis Foundation of America, the Bill and Melinda Gates Foundation, the HHMI and the NIH for support of work by the authors cited in this review.

PY - 2010/5/5

Y1 - 2010/5/5

N2 - Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.

AB - Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.

UR - https://www.scopus.com/pages/publications/77955874456

UR - https://www.scopus.com/pages/publications/77955874456#tab=citedBy

U2 - 10.1186/gb-2010-11-5-210

DO - 10.1186/gb-2010-11-5-210

M3 - Review article

C2 - 20441597

AN - SCOPUS:77955874456

SN - 1474-7596

VL - 11

JO - Genome biology

JF - Genome biology

IS - 5

M1 - 210

ER -

Direct sequencing of the human microbiome readily reveals community differences

Abstract

Bibliographical note

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