TY - JOUR
T1 - Direct gene delivery strategies for the treatment of rheumatoid arthritis
AU - Ghivizzani, Steven C.
AU - Oligino, Thomas J.
AU - Glorioso, Joseph C.
AU - Robbins, Paul D.
AU - Evans, Christopher H.
PY - 2001/3/1
Y1 - 2001/3/1
N2 - Gene therapy offers a novel and innovative approach to the delivery of therapeutic proteins to the joints of patients with arthritis. Several viral vectors, including adenovirus, adeno-associated virus, retrovirus and herpes simplex virus, are capable of delivering exogenous cDNAs to the synovial lining, enabling effective levels of intra-articular transgene expression following direct injection to the joint. The expression of certain gene products has proven to be sufficient to inhibit the progression of disease in animals with experimental arthritis. Non-viral methods of gene transfer, however, are less satisfactory, and are limited by toxicity and transience of expression. Although the principle of direct gene delivery to the joint has been demonstrated, maintaining persistent intra-articular transgene expression remains a challenge.
AB - Gene therapy offers a novel and innovative approach to the delivery of therapeutic proteins to the joints of patients with arthritis. Several viral vectors, including adenovirus, adeno-associated virus, retrovirus and herpes simplex virus, are capable of delivering exogenous cDNAs to the synovial lining, enabling effective levels of intra-articular transgene expression following direct injection to the joint. The expression of certain gene products has proven to be sufficient to inhibit the progression of disease in animals with experimental arthritis. Non-viral methods of gene transfer, however, are less satisfactory, and are limited by toxicity and transience of expression. Although the principle of direct gene delivery to the joint has been demonstrated, maintaining persistent intra-articular transgene expression remains a challenge.
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U2 - 10.1016/S1359-6446(01)01685-3
DO - 10.1016/S1359-6446(01)01685-3
M3 - Review article
AN - SCOPUS:0001762706
SN - 1359-6446
VL - 6
SP - 259
EP - 267
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 5
ER -