Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry

Jie Ting, Leslie Wilson, Sarah Jane Schwarzenberg, Ryan Himes, Bradley Barth, Melena D. Bellin, Peter R. Durie, Douglas S. Fishman, Steven D. Freedman, Cheryl E. Gariepy, Matthew J. Giefer, Tanja Gonska, Sohail Z. Husain, Soma Kumar, Veronique D. Morinville, Mark E. Lowe, Chee Y. Ooi, John F. Pohl, David Troendle, Danielle UsatinSteven L. Werlin, Michael Wilschanski, Melvin B. Heyman, Aliye Uc

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: To estimate selected direct medical care costs of children with chronic pancreatitis (CP) and acute recurrent pancreatitis (ARP). Methods: We performed a cross-sectional study of data from International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE), a multinational registry of children with ARP or CP. We determined health care utilization and estimated costs of hospitalizations, surgical and endoscopic procedures, and medications in our study population. Health care utilization data were obtained from all subjects enrolled in the study, and costs were calculated using national United States costs. Results: We included 224 subjects (median age 12.7 years), 42% of whomhad CP. Mean number of hospitalizations, including for surgery and endoscopic retrograde cholangiopancreatography, was 2.3 per person per year, costing an estimated average $38,755 per person per year. Including outpatient medications, estimated total mean cost was $40,589 per person per year. Subjects using surgical procedures or endoscopic retrograde cholangiopancreatography incurred mean annual costs of $42,951 per person and $12,035 per person, respectively. Estimated annual costs of pancreatic enzyme replacement therapy, diabetic medications, and painmedicationswere $4114, $1761, and $614 per person, respectively. In an exploratory analysis, patients with the following characteristics appear to accrue higher costs than those without them: more frequent ARP attacks per year, reported constant or episodic pain, family history of pancreatic cancer, and use of pain medication. Conclusions: ARP and CP are uncommon childhood conditions. The severe burden of disease associated with these conditions and their chronicity results in high health care utilization and costs. Interventions that reduce the need for hospitalization could lower costs for these children and their families.

Original languageEnglish (US)
Pages (from-to)443-449
Number of pages7
JournalJournal of pediatric gastroenterology and nutrition
Volume62
Issue number3
DOIs
StatePublished - Jan 1 2016

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Chronic Pancreatitis
Registries
Costs and Cost Analysis
Pancreatitis
Patient Acceptance of Health Care
Hospitalization
Endoscopic Retrograde Cholangiopancreatography
Health Care Costs
Enzyme Replacement Therapy
Pancreatic Neoplasms
Endoscopy
Outpatients
Cross-Sectional Studies
Pediatrics
Pain
Population

Keywords

  • Economic
  • Health care costs
  • Hospitalization
  • Pain
  • Quality of life

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Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry. / Ting, Jie; Wilson, Leslie; Schwarzenberg, Sarah Jane; Himes, Ryan; Barth, Bradley; Bellin, Melena D.; Durie, Peter R.; Fishman, Douglas S.; Freedman, Steven D.; Gariepy, Cheryl E.; Giefer, Matthew J.; Gonska, Tanja; Husain, Sohail Z.; Kumar, Soma; Morinville, Veronique D.; Lowe, Mark E.; Ooi, Chee Y.; Pohl, John F.; Troendle, David; Usatin, Danielle; Werlin, Steven L.; Wilschanski, Michael; Heyman, Melvin B.; Uc, Aliye.

In: Journal of pediatric gastroenterology and nutrition, Vol. 62, No. 3, 01.01.2016, p. 443-449.

Research output: Contribution to journalArticle

Ting, J, Wilson, L, Schwarzenberg, SJ, Himes, R, Barth, B, Bellin, MD, Durie, PR, Fishman, DS, Freedman, SD, Gariepy, CE, Giefer, MJ, Gonska, T, Husain, SZ, Kumar, S, Morinville, VD, Lowe, ME, Ooi, CY, Pohl, JF, Troendle, D, Usatin, D, Werlin, SL, Wilschanski, M, Heyman, MB & Uc, A 2016, 'Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry', Journal of pediatric gastroenterology and nutrition, vol. 62, no. 3, pp. 443-449. https://doi.org/10.1097/MPG.0000000000001057
Ting, Jie ; Wilson, Leslie ; Schwarzenberg, Sarah Jane ; Himes, Ryan ; Barth, Bradley ; Bellin, Melena D. ; Durie, Peter R. ; Fishman, Douglas S. ; Freedman, Steven D. ; Gariepy, Cheryl E. ; Giefer, Matthew J. ; Gonska, Tanja ; Husain, Sohail Z. ; Kumar, Soma ; Morinville, Veronique D. ; Lowe, Mark E. ; Ooi, Chee Y. ; Pohl, John F. ; Troendle, David ; Usatin, Danielle ; Werlin, Steven L. ; Wilschanski, Michael ; Heyman, Melvin B. ; Uc, Aliye. / Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry. In: Journal of pediatric gastroenterology and nutrition. 2016 ; Vol. 62, No. 3. pp. 443-449.
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T1 - Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry

AU - Ting, Jie

AU - Wilson, Leslie

AU - Schwarzenberg, Sarah Jane

AU - Himes, Ryan

AU - Barth, Bradley

AU - Bellin, Melena D.

AU - Durie, Peter R.

AU - Fishman, Douglas S.

AU - Freedman, Steven D.

AU - Gariepy, Cheryl E.

AU - Giefer, Matthew J.

AU - Gonska, Tanja

AU - Husain, Sohail Z.

AU - Kumar, Soma

AU - Morinville, Veronique D.

AU - Lowe, Mark E.

AU - Ooi, Chee Y.

AU - Pohl, John F.

AU - Troendle, David

AU - Usatin, Danielle

AU - Werlin, Steven L.

AU - Wilschanski, Michael

AU - Heyman, Melvin B.

AU - Uc, Aliye

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N2 - Objective: To estimate selected direct medical care costs of children with chronic pancreatitis (CP) and acute recurrent pancreatitis (ARP). Methods: We performed a cross-sectional study of data from International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE), a multinational registry of children with ARP or CP. We determined health care utilization and estimated costs of hospitalizations, surgical and endoscopic procedures, and medications in our study population. Health care utilization data were obtained from all subjects enrolled in the study, and costs were calculated using national United States costs. Results: We included 224 subjects (median age 12.7 years), 42% of whomhad CP. Mean number of hospitalizations, including for surgery and endoscopic retrograde cholangiopancreatography, was 2.3 per person per year, costing an estimated average $38,755 per person per year. Including outpatient medications, estimated total mean cost was $40,589 per person per year. Subjects using surgical procedures or endoscopic retrograde cholangiopancreatography incurred mean annual costs of $42,951 per person and $12,035 per person, respectively. Estimated annual costs of pancreatic enzyme replacement therapy, diabetic medications, and painmedicationswere $4114, $1761, and $614 per person, respectively. In an exploratory analysis, patients with the following characteristics appear to accrue higher costs than those without them: more frequent ARP attacks per year, reported constant or episodic pain, family history of pancreatic cancer, and use of pain medication. Conclusions: ARP and CP are uncommon childhood conditions. The severe burden of disease associated with these conditions and their chronicity results in high health care utilization and costs. Interventions that reduce the need for hospitalization could lower costs for these children and their families.

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KW - Health care costs

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