Direct Compression Tablet Containing 99% Active Ingredient—A Tale of Spherical Crystallization

Hongbo Chen, Aktham Aburub, Changquan Calvin Sun

Research output: Contribution to journalArticle

11 Scopus citations


Direct compression (DC) is the easiest and most cost-effective process for tablet manufacturing, because it only involves blending and compression. However, active pharmaceutical ingredients generally exhibit poor mechanical and micromeritic properties, which necessitate dilution and the use of high percentage of excipients to enable a robust DC manufacturing process. Consequently, drug loading in DC tablets is usually low (typically <30%, w/w). In this study, spherical crystallization by the quasi-emulsion solvent diffusion method was used to engineer a poorly flowing model compound, ferulic acid (FA), to attain superior mechanical properties, particle size distribution, and morphology. The engineered FA particles enabled the successful development of DC tablets containing 99% FA, which is in sharp contrast to the maximum 10% FA loading using as-received FA. The record high active pharmaceutical ingredient loading in this work illustrates the potential for spherical crystallization to enable high drug loading when developing a tablet product using the DC manufacturing process.

Original languageEnglish (US)
Pages (from-to)1396-1400
Number of pages5
JournalJournal of Pharmaceutical Sciences
Issue number4
StatePublished - Apr 2019


  • API loading
  • direct compression
  • flowability
  • quasi-emulsion solvent diffusion
  • tabletability

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

Fingerprint Dive into the research topics of 'Direct Compression Tablet Containing 99% Active Ingredient—A Tale of Spherical Crystallization'. Together they form a unique fingerprint.

  • Cite this