Direct cardiac effects of a novel vesamicol receptor ligand, m- iodobenzyl-trozamicol, assessed in the canine isolated, blood-perfused heart preparations

Atsushi Sugiyama, Keith G Lurie, Simon M.N. Efange, Shunji Takehana, Keitaro Hashimoto

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

MIBT, m-(iodobenzyl)trozamicol, is a recently discovered vesamicol analogue that can be used as a functional marker of cholinergic activity in the heart as well as the brain. The purpose of this study was to assess the effects of MIBT on sinus node automaticity, ventricular contraction, and coronary blood flow in addition to the action-potential duration of the ventricle by using canine isolated, blood-perfused sinoatrial node and papillary muscle preparations. Intracoronary administration of MIBT (1-300 μg) exerted negative chronotropic, inotropic, and coronary vasodilator effects in a dose-related manner. Pretreatment of the preparations with the muscarinic receptor antagonist atropine did not change these effects of MIBT. Moreover, MIBT had little effect on the repolarization phase of the ventricular action potential. Because the doses of MIBT needed for imaging cardiac cholinergic function were much lower than those affecting the cardiovascular system, MIBT may be used safely in future clinical applications.

Original languageEnglish (US)
Pages (from-to)843-847
Number of pages5
JournalJournal of Cardiovascular Pharmacology
Volume34
Issue number6
DOIs
StatePublished - Dec 1 1999

Keywords

  • Chronotropic
  • Coronary vasodilator
  • Inotropic
  • MIBT
  • Monophasic action potential
  • Vesamicol

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