Abstract
Diphenylene iodonium (DPI), an inhibitor of NAD(P)H oxidase, blocks hypoxic excitation of the carotid body. We use the whole-cell patch-clamp technique to investigate the actions of DPI on ionic currents in isolated type I carotid body cells. DPI (10 μM) caused reversible blockade of K+ and Ca2+ currents in these cells, indicating that DPI is a non-selective ion channel blocker. Since hypoxic excitation of the carotid body is dependent on Ca2+ influx into type I cells, our observation that DPI blocks Ca2+ currents in type I cells can account for the ability of this compound to inhibit hypoxic excitation of the intact organ.
Original language | English (US) |
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Pages (from-to) | 63-66 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 172 |
Issue number | 1-2 |
DOIs | |
State | Published - May 19 1994 |
Keywords
- Ca current
- Carotid body
- Chemoreceptor
- Diphenylene iodonium
- K current
- Type I cell