Dipeptidyl peptidase IV and incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study

Vivian C. Luft; Maria Inês Schmidt; James S. Pankow; Ron C. Hoogeveen; David Couper; Gerardo Heiss; Bruce B. Duncan

doi:10.2337/dc09-1996

Dipeptidyl peptidase IV and incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study

Vivian C. Luft, Maria Inês Schmidt, James S. Pankow, Ron C. Hoogeveen, David Couper, Gerardo Heiss, Bruce B. Duncan

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVE- Dipeptidyl peptidase IV (DPP-IV) is not only important in β-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes. RESEARCH DESIGN AND METHODS- Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over ∼9 years within the Atherosclerosis Risk in Communities study. RESULTS- In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations <0.11). Those who developed diabetes had mean DPP-IV values similar to those who did not (P = 0.18). Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62-1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors. CONCLUSIONS- Fasting DPP-IV levels do not appear to predict incident diabetes.

Original language	English (US)
Pages (from-to)	1109-1111
Number of pages	3
Journal	Diabetes care
Volume	33
Issue number	5
DOIs	https://doi.org/10.2337/dc09-1996
State	Published - May 2010

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title = "Dipeptidyl peptidase IV and incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study",

abstract = "OBJECTIVE- Dipeptidyl peptidase IV (DPP-IV) is not only important in β-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes. RESEARCH DESIGN AND METHODS- Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over ∼9 years within the Atherosclerosis Risk in Communities study. RESULTS- In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations <0.11). Those who developed diabetes had mean DPP-IV values similar to those who did not (P = 0.18). Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62-1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors. CONCLUSIONS- Fasting DPP-IV levels do not appear to predict incident diabetes.",

author = "Luft, {Vivian C.} and Schmidt, {Maria In{\^e}s} and Pankow, {James S.} and Hoogeveen, {Ron C.} and David Couper and Gerardo Heiss and Duncan, {Bruce B.}",

year = "2010",

month = may,

doi = "10.2337/dc09-1996",

language = "English (US)",

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publisher = "American Diabetes Association Inc.",

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T1 - Dipeptidyl peptidase IV and incident diabetes

T2 - The Atherosclerosis Risk in Communities (ARIC) study

AU - Luft, Vivian C.

AU - Schmidt, Maria Inês

AU - Pankow, James S.

AU - Hoogeveen, Ron C.

AU - Couper, David

AU - Heiss, Gerardo

AU - Duncan, Bruce B.

PY - 2010/5

Y1 - 2010/5

N2 - OBJECTIVE- Dipeptidyl peptidase IV (DPP-IV) is not only important in β-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes. RESEARCH DESIGN AND METHODS- Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over ∼9 years within the Atherosclerosis Risk in Communities study. RESULTS- In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations <0.11). Those who developed diabetes had mean DPP-IV values similar to those who did not (P = 0.18). Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62-1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors. CONCLUSIONS- Fasting DPP-IV levels do not appear to predict incident diabetes.

AB - OBJECTIVE- Dipeptidyl peptidase IV (DPP-IV) is not only important in β-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes. RESEARCH DESIGN AND METHODS- Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over ∼9 years within the Atherosclerosis Risk in Communities study. RESULTS- In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations <0.11). Those who developed diabetes had mean DPP-IV values similar to those who did not (P = 0.18). Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62-1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors. CONCLUSIONS- Fasting DPP-IV levels do not appear to predict incident diabetes.

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JF - Diabetes Care

SN - 1935-5548

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Dipeptidyl peptidase IV and incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study

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