Diffusion tensor imaging and Tract-Based Spatial Statistics in Alzheimer's disease and mild cognitive impairment

Yawu Liu, Gabriela Spulber, Kimmo K. Lehtimäki, Mervi Könönen, Ilona Hallikainen, Heidi Gröhn, Miia Kivipelto, Merja Hallikainen, Ritva Vanninen, Hilkka Soininen

Research output: Contribution to journalArticlepeer-review

173 Scopus citations


We aimed to explore the changes in fractional anisotropy (FA) in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) by analyzing diffusion tensor imaging (DTI) data using the Tract-Based Spatial Statistics (TBSS). DTI data were collected from 17 AD patients, 27 MCI subjects and 19 healthy controls. Voxel-based analysis with TBSS was used to compare FA among the three groups. Additionally, guided by TBSS findings, a region of interest (ROI)-based analysis along the TBSS skeleton was performed on group-level and the accuracy of the method was assessed by the back-projection of ROIs to the native space FA. Neurofiber tracts with decreased FA included: the parahippocampal white matter, cingulum, uncinate fasciculus, inferior and superior longitudinal fasciculus, corpus callosum, fornix, tracts in brain stem, and cerebellar tracts. Quantitative ROI-analysis further demonstrated the significant decrease on FA values in AD patients relative to controls whereas FA values of MCI patients were found in between the controls and AD patients. We conclude that TBSS is a promising method in examining the degeneration of neurofiber tracts in MCI and AD patients.

Original languageEnglish (US)
Pages (from-to)1558-1571
Number of pages14
JournalNeurobiology of Aging
Issue number9
StatePublished - Sep 2011
Externally publishedYes

Bibliographical note

Funding Information:
The study was supported by EU-regional Funds project 70068/2005 , AddNeuroMed/Innovative Medicines LSHB-CT-2005-518170 , Marie-Curie Program MEST CT-2005-019217 , Health Research Council of The Academy of Finland , grant 121038 , A.A. Laaksosen rahasto, and EVO grant 5772720 from Kuopio University Hospital .


  • Alzheimer's disease
  • Diagnostics
  • Diffusion tensor imaging
  • MRI
  • Mild cognitive impairment
  • Voxel-based method


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