Diffuse lymphadenopathy as a manifestation of ankylosing spondylitis

Paul R. Marantz, Mark Linzer

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Diffuse lymphadenopathy has not been previously described in association with ankylosing spondylitis. A 22-year-old man who presented with anorexia, weight loss, shoulder pain, and diffuse lymphadenopathy is described. Lymph node biopsy showed a nonspecific pattern of reactive hyperplasia with sinus histiocytosis. Clinical evaluation disclosed active spondylitis with HLA-B27 positivity. No other cause for the lymphadenopathy was found. The association between lymphadenopathy and connective tissue diseases is discussed. Ankylosing spondylitis should be added to the differential diagnosis of patients with generalized lymphadenopathy of uncertain cause.

Original languageEnglish (US)
Pages (from-to)951-953
Number of pages3
JournalThe American Journal of Medicine
Issue number5
StatePublished - May 1986


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