Differentiation versus plasticity: Fixing the fate of undetermined adult stem cells

Fikru Belema Bedada; Stefan Günther; Thomas Kubin; Thomas Braun

doi:10.4161/cc.5.3.2364

Differentiation versus plasticity: Fixing the fate of undetermined adult stem cells

Fikru Belema Bedada, Stefan Günther, Thomas Kubin, Thomas Braun

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Adult mesenchymal stem cells own a considerable plasticity, which enables them to respond to various extra- and intracellular cues and exert, at least partially, various differentiation pathways. Recently, we have shown that multipotent adult stem cells (MASCs) derived from the mouse bone marrow (mBM-MASCs) consist of distinct cell populations that have similar differentiation abilities but differ in the expression of several stem cell markers. Despite their remarkable developmental potential MASCs seem to miss crucial components to complete specific differentiation programs necessary to acquire a fully functional phenotype. A thorough analysis of active and inactive regulatory circuits in multipotent adult stem cells might lead the way to a controlled programming of these cells and rational therapeutic applications.

Original language	English (US)
Pages (from-to)	223-226
Number of pages	4
Journal	Cell Cycle
Volume	5
Issue number	3
DOIs	https://doi.org/10.4161/cc.5.3.2364
State	Published - Feb 1 2006
Externally published	Yes

Bibliographical note

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

Hybrid myotube
Plasticiy
Wnt-molecules
mBM-MASCs
β-catenin

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10.4161/cc.5.3.2364

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AU - Kubin, Thomas

AU - Braun, Thomas

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AB - Adult mesenchymal stem cells own a considerable plasticity, which enables them to respond to various extra- and intracellular cues and exert, at least partially, various differentiation pathways. Recently, we have shown that multipotent adult stem cells (MASCs) derived from the mouse bone marrow (mBM-MASCs) consist of distinct cell populations that have similar differentiation abilities but differ in the expression of several stem cell markers. Despite their remarkable developmental potential MASCs seem to miss crucial components to complete specific differentiation programs necessary to acquire a fully functional phenotype. A thorough analysis of active and inactive regulatory circuits in multipotent adult stem cells might lead the way to a controlled programming of these cells and rational therapeutic applications.

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Differentiation versus plasticity: Fixing the fate of undetermined adult stem cells

Abstract

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Keywords

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