Differentiation of U.S. and European isolates of porcine reproductive and respiratory syndrome virus by monoclonal antibodies

E. A. Nelson, J. Christopher-Hennings, T. Drew, G. Wensvoort, J. E. Collins, D. A. Benfield

Research output: Contribution to journalArticlepeer-review

305 Scopus citations

Abstract

Monoclonal antibodies (MAbs) to two U.S. isolates of porcine reproductive and respiratory syndrome (PRRS) virus were prepared. Two MAbs specifically recognized a conserved epitope on the putative 15-kDa nucleocapsid protein of U.S. and European isolates of PRRS virus. Four other MAbs recognized epitopes on the 15-kDa protein of U.S. but not European isolates of PRRS virus. Collectively, this indicates that PRRS viruses contain both conserved and divergent epitopes on the 15-kDa viral protein.

Original languageEnglish (US)
Pages (from-to)3184-3189
Number of pages6
JournalJournal of clinical microbiology
Volume31
Issue number12
DOIs
StatePublished - 1993

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