Abstract
The capacity of gelatin/chitosan/bioactive glass nanopowders (GEL/CS/BGNPs) scaffolds was investigated for increasing human endometrial stem cells (hEnSCs) differentiation into the endothelial cells in the presence of angiogenic factors. GEL/CS nanofibrous scaffold with different contents of BGNPs were fabricated and assessed. Expression of endothelial markers (CD31, vascular endothelial cadherin (VE-cadherin), and KDR) in differentiated cells was evaluated. Results showed the diameter of nanofiber increases with decreasing the BG content in GEL/CS scaffolds. Moreover, in vitro study indicated that the GEL/CS/BGNPs scaffold with 1.5% BGNPs content provided a suitable three-dimensional structure for endothelial cells differentiation. Thus, the GEL/CS/BGNPs scaffold can be recommended for blood vessels repair.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | Artificial Cells, Nanomedicine and Biotechnology |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2016 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 Taylor & Francis.
Keywords
- Endothelial cells
- Gelatin/chitosan/bioglass
- Human endometrial stem cells
- Nanofiber scaffold
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