Differentiation of CD8 T cells in response to acute and chronic viral infections: Implications for HIV vaccine development

J. D. Miller, D. Masopust, E. J. Wherry, S. Kaech, G. Silvestri, R. Ahmed

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Successful HIV vaccine strategies will likely require the induction of robust cellular immune responses, in addition to strong humoral responses. Unfortunately, there is no clear molecular definition of an effective HIV-specific CD8 T cell response. In this review, we discuss the differentiation of CD8 T cells in response to acute and chronic viral infections. We then apply concepts derived from these studies to predict the desirable characteristics of HIV-specific CD8 T cell memory.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalCurrent Drug Targets - Infectious Disorders
Volume5
Issue number2
DOIs
StatePublished - Jun 1 2005

Keywords

  • CD8 T cells
  • Differentiation
  • HIV vaccine
  • Immune memory
  • LCMV

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