Differential regulation of adrenal corticosteroids after restriction-induced drinking in rats

Cheryl Wotus, William C Engeland

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Water-restricted rats exhibit a rapid decrease in plasma corticosterone after drinking. The present study examined the effect of restriction-induced drinking on plasma aldosterone and plasma clearance of corticosterone. Rats were water restricted for 6-7 days and then killed before or 15 min after water administration; plasma and adrenal hormones were assayed. Plasma and adrenal corticosterone decreased after drinking without a change in plasma corticosteroid-binding globulin; plasma ACTH decreased or did not change. In contrast, plasma aldosterone did not change or increased after drinking; plasma renin activity was elevated by water restriction and increased further after drinking. In another experiment, rats were adrenalectomized, and corticosterone and aldosterone were replaced with pellets and osmotic minipumps, respectively. Rats were water restricted and killed. There was a small decrease in plasma corticosterone but no change in aldosterone after drinking in adrenalectomized animals. These data suggest that changes in plasma steroids after restriction-induced drinking result from zone-specific responses of the adrenal to known secretagogues, with minimal contribution from increased plasma clearance.

Original languageEnglish (US)
Pages (from-to)R183-R191
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number1 53-1
StatePublished - Jan 1 2003


  • Aldosterone
  • Corticosteroid-binding globulin
  • Corticosterone
  • Dehydration
  • Steroid clearance


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