Differential processing of decision information in subregions of rodent medial prefrontal cortex

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5 Scopus citations


Decision-making involves multiple cognitive processes requiring different aspects of information about the situation at hand. The rodent medial prefrontal cortex (mPFC) has been hypothesized to be central to these abilities. Functional studies have sought to link specific processes to specific anatomical subregions, but past studies of mPFC have yielded controversial results, leaving the precise nature of mPFC function unclear. To settle this debate, we recorded from the full dorso-ventral extent of mPFC in each of 8 rats, as they performed a complex economic decision task. These data revealed four distinct functional domains within mPFC that closely mirrored anatomically identified subregions, including novel evidence to divide prelimbic cortex into dorsal and ventral components. We found that dorsal aspects of mPFC (ACC, dPL) were more involved in processing information about active decisions, while ventral aspects (vPL, IL) were more engaged in motivational factors.

Original languageEnglish (US)
Article numbere82833
StatePublished - Jan 18 2023

Bibliographical note

Funding Information:
We thank K Seeland, C Boldt, A Sheehan, and C Bogner for technical assistance as well as members of the Redish lab for useful discussion. We also thank S Heilbronner for discussion and guidance regarding prefrontal anatomy, and the G Buszáki lab for guidance on silicon probe recordings. This work was supported by NIH grants R01-MH112688 and T32-MH115886.

Publisher Copyright:
© 2023, eLife Sciences Publications Ltd. All rights reserved.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural


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