Abstract
We describe a differential phase low-coherence interferometric probe for non-invasive, quantitative imaging of photothermal phenomena in biological materials. Our detection method utilizes principles of optical coherence tomography with differential phase measurement of interference fringe signals. A dual-channel optical low-coherence probe is used to analyse laser-induced thermoelastic and thermorefractive effects in tissue with micrometre axial resolution and nanometre sensitivity. We demonstrate an application of the technique using tissue phantoms and ex-vivo tissue specimens of rodent dorsal skin.
Original language | English (US) |
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Pages (from-to) | 111-119 |
Number of pages | 9 |
Journal | Physics in Medicine and Biology |
Volume | 49 |
Issue number | 1 |
DOIs | |
State | Published - Jan 7 2004 |