Differential phase optical coherence probe for depth-resolved detection of photothermal response in tissue

Sergey A. Telenkov, Digant P. Dave, Shriram Sethuraman, Taner Akkin, Thomas E. Milner

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We describe a differential phase low-coherence interferometric probe for non-invasive, quantitative imaging of photothermal phenomena in biological materials. Our detection method utilizes principles of optical coherence tomography with differential phase measurement of interference fringe signals. A dual-channel optical low-coherence probe is used to analyse laser-induced thermoelastic and thermorefractive effects in tissue with micrometre axial resolution and nanometre sensitivity. We demonstrate an application of the technique using tissue phantoms and ex-vivo tissue specimens of rodent dorsal skin.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalPhysics in Medicine and Biology
Volume49
Issue number1
DOIs
StatePublished - Jan 7 2004

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