Differential optical imaging in animal models using infrared transillumination

Sanhita Dixit, Theresamai Le, Khalid Amin, Gregory W. Faris

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrate the use of diffuse optical imaging via transillumination to detect cancerous tissue in a rat animal model. In this imaging modality infrared radiation is transmitted through whole animal tissue. The radiation is nonionizing and uses endogenous contrast: namely deoxyhemoglobin (Hb) and oxyhemoglobin (HbO). Differential image analysis is performed to visualize the presence of cancerous tissue. Varying levels of inspired air and carbogen gases ensure a differential response in absorption by blood due to changing levels of Hb and HbO. We believe that this response may be sufficient to provide contrast in differential image analysis. The present method also sheds light on physiological challenges in whole animal imaging especially with respect to significant optical signals from healthy tissue. Specifically, we have seen strong signals from abdominal regions in normal rats indicative of diet related anomalous transmission. We have also been able to track the changes in optical signal during animal death.

Original languageEnglish (US)
Title of host publicationOptical Tomography and Spectroscopy of Tissue VII
Volume6434
DOIs
StatePublished - Apr 30 2007
EventOptical Tomography and Spectroscopy of Tissue VII - San Jose, CA, United States
Duration: Jan 21 2007Jan 24 2007

Other

OtherOptical Tomography and Spectroscopy of Tissue VII
Country/TerritoryUnited States
CitySan Jose, CA
Period1/21/071/24/07

Keywords

  • Cancer
  • Differential imaging
  • Near infrared
  • Optical imaging
  • Tissue

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