Differential inhibition of macrophage activation by lymphocytic choriomeningitis virus and Pichinde virus is mediated by the Z protein N-terminal domain

Junji Xing, Zheng Chai, Hinh Ly, Yuying Liang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Several arenavirus pathogens, such as Lassa and Junin viruses, inhibit macrophage activation, the molecular mechanism of which is unclear. We show that lymphocytic choriomeningitis virus (LCMV) can also inhibit macrophage activation, in contrast to Pichinde and Tacaribe viruses, which are not known to naturally cause human diseases. Using a recombinant Pichinde virus system, we show that the LCMV Z N-terminal domain (NTD) mediates the inhibition of macrophage activation and immune functions.

Original languageEnglish (US)
Pages (from-to)12513-12517
Number of pages5
JournalJournal of virology
Volume89
Issue number24
DOIs
StatePublished - 2015

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