Differential gene expression profiles of Jnk1-and Jnk2-deficient murine fibroblast cells

Nanyue Chen, Qing Bai She, Ann M. Bode, Zigang Dong

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

c-Jun NH2-terminal kinase (JNK) 1 and JNK2 have been assumed to complement each other and mediate the same or similar biological functions. However, our recent reports indicated that 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced tumor development is suppressed in Jnk2 knockout mice but enhanced in Jnk1 knockout mice. In the present work, primary embryo cells were isolated from wild-type, Jnk1-/- and Jnk2-/- mice and used for cDNA microarray analysis. The patterns of gene expression in Jnk1-/-, Jnk2-/-, and wild-type cells are different. After 12-O-tetradecanoylphorbol-13-acetate treatment, the changes in the gene expression profiles in three different kinds of cells appear to agree with the differences in susceptibility to tumori-genesis of each respective animal model. These results suggest that JNK1 and JNK2 proteins have different roles in modulating cell function.

Original languageEnglish (US)
Pages (from-to)1300-1304
Number of pages5
JournalCancer Research
Volume62
Issue number5
StatePublished - Mar 1 2002

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