Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue

Xiaohua Wei, Harry T. Orr

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


The data presented here demonstrated that the HLA-G class I gene is unique among the members of the human class I gene family in that its expression is restricted to extraembryonic tissues during gestation. Furthermore, the pattern of HLA-G expression in these tissues changes as gestation proceeds. During first trimester HLA-G is expressed within the placenta and not within the extravillous membrane. At term, the pattern of the HLA-G expression is reversed, extravillous membrane expressed HLA-G while placenta does not. Another non-HLA-A, -B, -C class I gene, HLA-E, is also expressed by extraembryonic tissues. Unlike HLA-G, HLA-E is expressed by both placenta and extravillous membrane at first trimester and at term. These results raise the intriguing possbility that the HLA-G-encoded molecule has a role in embryonic development and/or the fetal-maternal immune response.

Original languageEnglish (US)
Pages (from-to)131-142
Number of pages12
JournalHuman Immunology
Issue number2
StatePublished - Oct 1990

Bibliographical note

Funding Information:
This work was supported by Grant AI-18124 from the National Institutes of Health and by Grant IM-379D from the American Cancer Society.


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