Differential electrophysiological coupling for positive and negative BOLD responses during unilateral hand movements

Han Yuan, Christopher Perdoni, Lin Yang, Bin He

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The coupling between neural cellular activity and blood oxygen level-dependent (BOLD) signal is of critical importance to the interpretation of fMRI. Largely unknown, however, is the degree to which different neuronal events (i.e., excitation and inhibition) maintain or disrupt the neural-hemodynamic relationship, especially in humans. In the present study, we compared local electroencephalographic (EEG) oscillations and the positive/negative BOLD responses of simultaneously recorded data from healthy human volunteers performing unilateral finger tapping at graded rates. By quantifying the single-trial modulations of EEG using source imaging, we tested for their correlation with positive BOLD response (PBR) and negative BOLD response (NBR) after coregistering their spatial locations. PBR was found to be overlapped with and correlated to the decrease of alpha (8 -13 Hz) and beta (13-30 Hz) band EEG in the contralateral sensorimotor cortex. Regional EEG modulations at the sensorimotor cortex further predicted a spatially distributed and interconnected network of motor-related cortical areas. Alternatively, no significant correlation was found at the ipsilateral sensorimotor cortex between the NBR and EEG despite their spatial overlapping. This differential electrophysiological coupling of the positive and negative BOLD responses suggests that the underlying neuronal events may not only influence the direction of the signal change but also the neural- hemodynamic relationship. Copyright

Original languageEnglish (US)
Pages (from-to)9585-9593
Number of pages9
JournalJournal of Neuroscience
Volume31
Issue number26
DOIs
StatePublished - Jun 29 2011

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