Differential effects of morphine and cocaine on locomotor activity and sensitization in μ-opioid receptor knockout mice

Ji Hoon Yoo; Eun Mi Yang; Seok Yong Lee; Horace H. Loh; Ing K. Ho; Choon Gon Jang

doi:10.1016/S0304-3940(03)00410-5

Differential effects of morphine and cocaine on locomotor activity and sensitization in μ-opioid receptor knockout mice

Ji Hoon Yoo
, Eun Mi Yang
, Seok Yong Lee
, Horace H. Loh
, Ing K. Ho
, Choon Gon Jang

Pharmacology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The present study was undertaken to investigate the hypothesis that the μ-opioid receptors play a crucial role in locomotor activity and sensitization to cocaine and morphine in wild-type and μ-opioid receptor knockout mice. Our results show that morphine and cocaine increased locomotor activity in wild-type mice, but failed to increase locomotor activity in μ-opioid receptor knockout mice, suggesting a contribution of μ-opioid receptor. Repeated morphine treatment induced sensitization in wild-type mice, but this was not observed in μ-opioid receptor knockout mice. In contrast repeated cocaine treatment produced sensitization in μ-opioid receptor knockout mice, but not in wild-type mice on day 6. However, the sensitization to cocaine was observed in μ-opioid receptor knockout and wild-type mice on day 12. These results suggest that the expression of μ-opioid receptor may contribute to locomotor sensitization induced by morphine, but that μ-opioid receptor does not play an important role in mediating sensitization to cocaine.

Original language	English (US)
Pages (from-to)	37-40
Number of pages	4
Journal	Neuroscience Letters
Volume	344
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(03)00410-5
State	Published - Jun 19 2003

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (02-PJ1-PG3-21301-0017). The authors thank Dr E.-Y. Cha and Mr S.-G. Lee for providing a automated analysis system (NeuroVison).

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Behavioral sensitization
Cocaine
Knockout mice
Locomotor activity
Morphine
μ-Opioid receptors

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10.1016/S0304-3940(03)00410-5

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title = "Differential effects of morphine and cocaine on locomotor activity and sensitization in μ-opioid receptor knockout mice",

abstract = "The present study was undertaken to investigate the hypothesis that the μ-opioid receptors play a crucial role in locomotor activity and sensitization to cocaine and morphine in wild-type and μ-opioid receptor knockout mice. Our results show that morphine and cocaine increased locomotor activity in wild-type mice, but failed to increase locomotor activity in μ-opioid receptor knockout mice, suggesting a contribution of μ-opioid receptor. Repeated morphine treatment induced sensitization in wild-type mice, but this was not observed in μ-opioid receptor knockout mice. In contrast repeated cocaine treatment produced sensitization in μ-opioid receptor knockout mice, but not in wild-type mice on day 6. However, the sensitization to cocaine was observed in μ-opioid receptor knockout and wild-type mice on day 12. These results suggest that the expression of μ-opioid receptor may contribute to locomotor sensitization induced by morphine, but that μ-opioid receptor does not play an important role in mediating sensitization to cocaine.",

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note = "Funding Information: This study was supported by a grant of the Korea Health 21 R\&D Project, Ministry of Health \& Welfare, Republic of Korea (02-PJ1-PG3-21301-0017). The authors thank Dr E.-Y. Cha and Mr S.-G. Lee for providing a automated analysis system (NeuroVison). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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AU - Ho, Ing K.

AU - Jang, Choon Gon

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N2 - The present study was undertaken to investigate the hypothesis that the μ-opioid receptors play a crucial role in locomotor activity and sensitization to cocaine and morphine in wild-type and μ-opioid receptor knockout mice. Our results show that morphine and cocaine increased locomotor activity in wild-type mice, but failed to increase locomotor activity in μ-opioid receptor knockout mice, suggesting a contribution of μ-opioid receptor. Repeated morphine treatment induced sensitization in wild-type mice, but this was not observed in μ-opioid receptor knockout mice. In contrast repeated cocaine treatment produced sensitization in μ-opioid receptor knockout mice, but not in wild-type mice on day 6. However, the sensitization to cocaine was observed in μ-opioid receptor knockout and wild-type mice on day 12. These results suggest that the expression of μ-opioid receptor may contribute to locomotor sensitization induced by morphine, but that μ-opioid receptor does not play an important role in mediating sensitization to cocaine.

AB - The present study was undertaken to investigate the hypothesis that the μ-opioid receptors play a crucial role in locomotor activity and sensitization to cocaine and morphine in wild-type and μ-opioid receptor knockout mice. Our results show that morphine and cocaine increased locomotor activity in wild-type mice, but failed to increase locomotor activity in μ-opioid receptor knockout mice, suggesting a contribution of μ-opioid receptor. Repeated morphine treatment induced sensitization in wild-type mice, but this was not observed in μ-opioid receptor knockout mice. In contrast repeated cocaine treatment produced sensitization in μ-opioid receptor knockout mice, but not in wild-type mice on day 6. However, the sensitization to cocaine was observed in μ-opioid receptor knockout and wild-type mice on day 12. These results suggest that the expression of μ-opioid receptor may contribute to locomotor sensitization induced by morphine, but that μ-opioid receptor does not play an important role in mediating sensitization to cocaine.

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Differential effects of morphine and cocaine on locomotor activity and sensitization in μ-opioid receptor knockout mice

Abstract

Bibliographical note

UN SDGs

Keywords

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