Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain

Anne M. Maliszewski-Hall; Michelle Alexander; Ivan Tkáč; Gülin Öz; Raghavendra Rao

doi:10.1007/s11064-015-1609-y

Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain

Anne M. Maliszewski-Hall, Michelle Alexander, Ivan Tkáč, Gülin Öz, Raghavendra Rao

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6 Scopus citations

Abstract

Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo ¹H magnetic resonance (MR) spectroscopy at 9.4 T. IUGR was induced via bilateral uterine artery ligation at gestational day 19 in pregnant Sprague–Dawley dams. MR spectra were obtained from the cerebral cortex, hippocampus and striatum at P7 in IUGR (N = 12) and NG (N = 13) rats. In the cortex, IUGR resulted in lower concentrations of phosphocreatine, glutathione, taurine, total choline, total creatine (P < 0.01) and [glutamate]/[glutamine] ratio (P < 0.05). Lower taurine concentrations were observed in the hippocampus (P < 0.01) and striatum (P < 0.05). IUGR differentially affects the neurochemical profile of the P7 rat brain regions. Persistent neurochemical changes may lead to cortex-based long-term neurodevelopmental deficits in human IUGR infants.

Original language	English (US)
Pages (from-to)	133-140
Number of pages	8
Journal	Neurochemical Research
Volume	42
Issue number	1
DOIs	https://doi.org/10.1007/s11064-015-1609-y
State	Published - Jan 1 2017

Bibliographical note

Funding Information:
The authors thank Dinesh Deelchand, Ph.D. for advice and assistance in spectral processing and quantification, Michael Georgieff, M.D. for critical review of the manuscript and Rebecca Simmons, M.D. for technical and intellectual support. The National Institute of Health (CHRCDA K12 HD068322), Bethesda, Maryland, the Viking Children’s Fund, Department of Pediatrics, University of Minnesota, Minneapolis, MN and the WM KECK Foundation “A Multi-Mode Multi-Channel Transmitter for 9.4 T NMR” supported this project. The Center for Magnetic Resonance Research is supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) Grant P41EB015894, the Institutional Center for Cores for Advanced Neuroimaging Award P30 NS076408 and the WM KECK Foundation.

Publisher Copyright:
© 2015, Springer Science+Business Media New York.

Keywords

Brain
IUGR
Magnetic resonance spectroscopy
Metabolism

Publisher link

10.1007/s11064-015-1609-y

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783286

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title = "Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain",

abstract = "Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spectroscopy at 9.4 T. IUGR was induced via bilateral uterine artery ligation at gestational day 19 in pregnant Sprague–Dawley dams. MR spectra were obtained from the cerebral cortex, hippocampus and striatum at P7 in IUGR (N = 12) and NG (N = 13) rats. In the cortex, IUGR resulted in lower concentrations of phosphocreatine, glutathione, taurine, total choline, total creatine (P < 0.01) and [glutamate]/[glutamine] ratio (P < 0.05). Lower taurine concentrations were observed in the hippocampus (P < 0.01) and striatum (P < 0.05). IUGR differentially affects the neurochemical profile of the P7 rat brain regions. Persistent neurochemical changes may lead to cortex-based long-term neurodevelopmental deficits in human IUGR infants.",

keywords = "Brain, IUGR, Magnetic resonance spectroscopy, Metabolism",

author = "Maliszewski-Hall, {Anne M.} and Michelle Alexander and Ivan Tk{\'a}{\v c} and G{\"u}lin {\"O}z and Raghavendra Rao",

note = "Funding Information: The authors thank Dinesh Deelchand, Ph.D. for advice and assistance in spectral processing and quantification, Michael Georgieff, M.D. for critical review of the manuscript and Rebecca Simmons, M.D. for technical and intellectual support. The National Institute of Health (CHRCDA K12 HD068322), Bethesda, Maryland, the Viking Children{\textquoteright}s Fund, Department of Pediatrics, University of Minnesota, Minneapolis, MN and the WM KECK Foundation “A Multi-Mode Multi-Channel Transmitter for 9.4 T NMR” supported this project. The Center for Magnetic Resonance Research is supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) Grant P41EB015894, the Institutional Center for Cores for Advanced Neuroimaging Award P30 NS076408 and the WM KECK Foundation. Publisher Copyright: {\textcopyright} 2015, Springer Science+Business Media New York.",

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AU - Öz, Gülin

AU - Rao, Raghavendra

N1 - Funding Information: The authors thank Dinesh Deelchand, Ph.D. for advice and assistance in spectral processing and quantification, Michael Georgieff, M.D. for critical review of the manuscript and Rebecca Simmons, M.D. for technical and intellectual support. The National Institute of Health (CHRCDA K12 HD068322), Bethesda, Maryland, the Viking Children’s Fund, Department of Pediatrics, University of Minnesota, Minneapolis, MN and the WM KECK Foundation “A Multi-Mode Multi-Channel Transmitter for 9.4 T NMR” supported this project. The Center for Magnetic Resonance Research is supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) Grant P41EB015894, the Institutional Center for Cores for Advanced Neuroimaging Award P30 NS076408 and the WM KECK Foundation. Publisher Copyright: © 2015, Springer Science+Business Media New York.

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N2 - Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spectroscopy at 9.4 T. IUGR was induced via bilateral uterine artery ligation at gestational day 19 in pregnant Sprague–Dawley dams. MR spectra were obtained from the cerebral cortex, hippocampus and striatum at P7 in IUGR (N = 12) and NG (N = 13) rats. In the cortex, IUGR resulted in lower concentrations of phosphocreatine, glutathione, taurine, total choline, total creatine (P < 0.01) and [glutamate]/[glutamine] ratio (P < 0.05). Lower taurine concentrations were observed in the hippocampus (P < 0.01) and striatum (P < 0.05). IUGR differentially affects the neurochemical profile of the P7 rat brain regions. Persistent neurochemical changes may lead to cortex-based long-term neurodevelopmental deficits in human IUGR infants.

AB - Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spectroscopy at 9.4 T. IUGR was induced via bilateral uterine artery ligation at gestational day 19 in pregnant Sprague–Dawley dams. MR spectra were obtained from the cerebral cortex, hippocampus and striatum at P7 in IUGR (N = 12) and NG (N = 13) rats. In the cortex, IUGR resulted in lower concentrations of phosphocreatine, glutathione, taurine, total choline, total creatine (P < 0.01) and [glutamate]/[glutamine] ratio (P < 0.05). Lower taurine concentrations were observed in the hippocampus (P < 0.01) and striatum (P < 0.05). IUGR differentially affects the neurochemical profile of the P7 rat brain regions. Persistent neurochemical changes may lead to cortex-based long-term neurodevelopmental deficits in human IUGR infants.

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Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain

Abstract

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