Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain

Anne M Maliszewski Hall, Michelle A Curtis, Ivan Tkac, Gulin Oz, Raghu Rao

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spectroscopy at 9.4 T. IUGR was induced via bilateral uterine artery ligation at gestational day 19 in pregnant Sprague–Dawley dams. MR spectra were obtained from the cerebral cortex, hippocampus and striatum at P7 in IUGR (N = 12) and NG (N = 13) rats. In the cortex, IUGR resulted in lower concentrations of phosphocreatine, glutathione, taurine, total choline, total creatine (P < 0.01) and [glutamate]/[glutamine] ratio (P < 0.05). Lower taurine concentrations were observed in the hippocampus (P < 0.01) and striatum (P < 0.05). IUGR differentially affects the neurochemical profile of the P7 rat brain regions. Persistent neurochemical changes may lead to cortex-based long-term neurodevelopmental deficits in human IUGR infants.

Original languageEnglish (US)
Pages (from-to)133-140
Number of pages8
JournalNeurochemical Research
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Rats
Brain
Growth
Hippocampus
Taurine
Cerebral Cortex
Magnetic Resonance Spectroscopy
Magnetic resonance spectroscopy
Uterine Artery
Phosphocreatine
Creatine
Magnetic resonance
Choline
Glutamine
Dams
Glutathione
Ligation
Glutamic Acid

Keywords

  • Brain
  • IUGR
  • Magnetic resonance spectroscopy
  • Metabolism

Cite this

Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain. / Maliszewski Hall, Anne M; Curtis, Michelle A; Tkac, Ivan; Oz, Gulin; Rao, Raghu.

In: Neurochemical Research, Vol. 42, No. 1, 01.01.2017, p. 133-140.

Research output: Contribution to journalArticle

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