Differential effect of aspirin versus warfarin on clinical stroke types in patients with atrial fibrillation

V. T. Miller; L. A. Pearce; W. M. Feinberg; J. F. Rothrock; D. C. Anderson; R. G. Hart

doi:10.1212/WNL.46.1.238

Differential effect of aspirin versus warfarin on clinical stroke types in patients with atrial fibrillation

V. T. Miller, L. A. Pearce, W. M. Feinberg, J. F. Rothrock, D. C. Anderson, R. G. Hart

Neurology

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57 Scopus citations

Abstract

The Stroke Prevention in Atrial Fibrillation II study compared the efficacy and safety of aspirin and warfarin in patients with atrial fibrillation. Three neurologists, blinded to patient therapy, categorized the pathophysiology of ischemic strokes that occurred in the trial based on predetermined clinical criteria. Upon analyzing the patients being treated with these two drugs, warfarin proved significantly more effective than aspirin in preventing cardioembolic strokes (p = 0.005) and strokes of uncertain pathophysiology (p = 0.01). There was no significant difference in the efficacy for prevention of noncardioembolic strokes.

Original language	English (US)
Pages (from-to)	238-240
Number of pages	3
Journal	Neurology
Volume	46
Issue number	1
DOIs	https://doi.org/10.1212/WNL.46.1.238
State	Published - Jan 1996

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abstract = "The Stroke Prevention in Atrial Fibrillation II study compared the efficacy and safety of aspirin and warfarin in patients with atrial fibrillation. Three neurologists, blinded to patient therapy, categorized the pathophysiology of ischemic strokes that occurred in the trial based on predetermined clinical criteria. Upon analyzing the patients being treated with these two drugs, warfarin proved significantly more effective than aspirin in preventing cardioembolic strokes (p = 0.005) and strokes of uncertain pathophysiology (p = 0.01). There was no significant difference in the efficacy for prevention of noncardioembolic strokes.",

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AU - Pearce, L. A.

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AU - Rothrock, J. F.

AU - Anderson, D. C.

AU - Hart, R. G.

PY - 1996/1

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AB - The Stroke Prevention in Atrial Fibrillation II study compared the efficacy and safety of aspirin and warfarin in patients with atrial fibrillation. Three neurologists, blinded to patient therapy, categorized the pathophysiology of ischemic strokes that occurred in the trial based on predetermined clinical criteria. Upon analyzing the patients being treated with these two drugs, warfarin proved significantly more effective than aspirin in preventing cardioembolic strokes (p = 0.005) and strokes of uncertain pathophysiology (p = 0.01). There was no significant difference in the efficacy for prevention of noncardioembolic strokes.

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Differential effect of aspirin versus warfarin on clinical stroke types in patients with atrial fibrillation

Abstract

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