Differential cytotoxic activity of the petroleum ether extract and its furanosesquiterpenoid constituents from Commiphora molmol resin

Seif Eldin N Ayyad; Thomas R. Hoye; Walied M. Alarif; Sana'a M. Al Ahmadi; Salim A. Basaif; Mohamed A. Ghandourah; Farid A. Badria

doi:10.1515/znc-2014-4191

Differential cytotoxic activity of the petroleum ether extract and its furanosesquiterpenoid constituents from Commiphora molmol resin

Seif Eldin N Ayyad, Thomas R. Hoye, Walied M. Alarif, Sana'a M. Al Ahmadi, Salim A. Basaif, Mohamed A. Ghandourah, Farid A. Badria

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Abstract

This study revealed a differential cytotoxic activity of the petroleum ether extract (IC50 = 5 μg/mL) of the resinous exudates of Commiphora molmol against two mouse cell lines KA31T and NIH3T3 (untransformed and transformed mouse fibroblasts, respectively). Four new compounds (1-4) and five known compounds (5-9) were isolated from the petroleum ether extract. The identity of these new compounds was determined as γ-elemane lactone (1), 5-αH,8-βH-eudesma-1,3,7(11)-trien-8,12-olide (2), 2-hydroxy-11,12-dihydrofuranodiene (3), and 2-hydroxyfuranodiene (4). 1 and 2 displayed the highest cytotoxic activity against NIH3T3 cells. 7 and 9 exhibited moderate cytotoxic activity against KA31T cells. Compounds 3-6 showed weak cytotoxic activities against both cell lines. These results may explain the high efficacy of the petroleum ether fraction in several myrrh-derived pharmaceutical preparations.

Original language	English (US)
Pages (from-to)	87-92
Number of pages	6
Journal	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume	70
Issue number	3-4
DOIs	https://doi.org/10.1515/znc-2014-4191
State	Published - Mar 1 2015

Keywords

Cytotoxicity
KA31T
Myrrh resin
NIH3T3
Sesquiterpenoids.

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10.1515/znc-2014-4191

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Ayyad, S. E. N., Hoye, T. R., Alarif, W. M., Al Ahmadi, S. M., Basaif, S. A., Ghandourah, M. A., & Badria, F. A. (2015). Differential cytotoxic activity of the petroleum ether extract and its furanosesquiterpenoid constituents from Commiphora molmol resin. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 70(3-4), 87-92. https://doi.org/10.1515/znc-2014-4191

Differential cytotoxic activity of the petroleum ether extract and its furanosesquiterpenoid constituents from Commiphora molmol resin. / Ayyad, Seif Eldin N; Hoye, Thomas R.; Alarif, Walied M. et al.
In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 70, No. 3-4, 01.03.2015, p. 87-92.

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abstract = "This study revealed a differential cytotoxic activity of the petroleum ether extract (IC50 = 5 μg/mL) of the resinous exudates of Commiphora molmol against two mouse cell lines KA31T and NIH3T3 (untransformed and transformed mouse fibroblasts, respectively). Four new compounds (1-4) and five known compounds (5-9) were isolated from the petroleum ether extract. The identity of these new compounds was determined as γ-elemane lactone (1), 5-αH,8-βH-eudesma-1,3,7(11)-trien-8,12-olide (2), 2-hydroxy-11,12-dihydrofuranodiene (3), and 2-hydroxyfuranodiene (4). 1 and 2 displayed the highest cytotoxic activity against NIH3T3 cells. 7 and 9 exhibited moderate cytotoxic activity against KA31T cells. Compounds 3-6 showed weak cytotoxic activities against both cell lines. These results may explain the high efficacy of the petroleum ether fraction in several myrrh-derived pharmaceutical preparations.",

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AU - Al Ahmadi, Sana'a M.

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AU - Ghandourah, Mohamed A.

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N2 - This study revealed a differential cytotoxic activity of the petroleum ether extract (IC50 = 5 μg/mL) of the resinous exudates of Commiphora molmol against two mouse cell lines KA31T and NIH3T3 (untransformed and transformed mouse fibroblasts, respectively). Four new compounds (1-4) and five known compounds (5-9) were isolated from the petroleum ether extract. The identity of these new compounds was determined as γ-elemane lactone (1), 5-αH,8-βH-eudesma-1,3,7(11)-trien-8,12-olide (2), 2-hydroxy-11,12-dihydrofuranodiene (3), and 2-hydroxyfuranodiene (4). 1 and 2 displayed the highest cytotoxic activity against NIH3T3 cells. 7 and 9 exhibited moderate cytotoxic activity against KA31T cells. Compounds 3-6 showed weak cytotoxic activities against both cell lines. These results may explain the high efficacy of the petroleum ether fraction in several myrrh-derived pharmaceutical preparations.

AB - This study revealed a differential cytotoxic activity of the petroleum ether extract (IC50 = 5 μg/mL) of the resinous exudates of Commiphora molmol against two mouse cell lines KA31T and NIH3T3 (untransformed and transformed mouse fibroblasts, respectively). Four new compounds (1-4) and five known compounds (5-9) were isolated from the petroleum ether extract. The identity of these new compounds was determined as γ-elemane lactone (1), 5-αH,8-βH-eudesma-1,3,7(11)-trien-8,12-olide (2), 2-hydroxy-11,12-dihydrofuranodiene (3), and 2-hydroxyfuranodiene (4). 1 and 2 displayed the highest cytotoxic activity against NIH3T3 cells. 7 and 9 exhibited moderate cytotoxic activity against KA31T cells. Compounds 3-6 showed weak cytotoxic activities against both cell lines. These results may explain the high efficacy of the petroleum ether fraction in several myrrh-derived pharmaceutical preparations.

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Differential cytotoxic activity of the petroleum ether extract and its furanosesquiterpenoid constituents from Commiphora molmol resin

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