Diferenças na apresentação clínico- radiológica da tuberculose intratorácica segundo a presença ou não de infecção por HIV

Translated title of the contribution: Differences in the clinical and radiological presentation of intrathoracic tuberculosis in the presence or absence of HIV infection

Pedro Dornelles Picon, Maria Luiza Avancini Caramori, Sérgio Luiz Bassanesi, Sandra Jungblut, Marcelo Folgierini, Nelson Da Silva Porto, Carlos Fernando Carvalho Rizzon, Roberto Luiz Targa Ferreira, Tânia Mariza De Freitas, Carla Adriane Jarczewski

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Objective: To describe the differences in the clinical and radiological presentation of tuberculosis in the presence or absence of HlV infection. Methods: A sample of 231 consecutive adults with active pulmonary tuberculosis admitted to a tuberculosis hospital were studied, assessing HIV infection, AIDS, and associated factors, as well as re-evaluating chest X-rays. Results: There were 113 HIV-positive patients (49%) Comparing the 113 HIV-positive patients (49%) to the 118 HIV-negative patients (51%), the former presented a higher frequency of atypical pulmonary tuberculosis (pulmonary lesions accompanied by intrathoracic lymph node enlargement), hematogenous tuberculosis, and pulmonary tuberculosis accompanied by superficial lymph node enlargement, as well as presenting less pulmonary cavitation. The same was found when HIV-positive patients with AIDS were compared to those without AIDS. There were no differences between the HIV-positive patients without AIDS and the HIV-negative patients. Median CD4 counts were lower in HIV-positive patients with intrathoracic lymph node enlargement and pulmonary lesions than in the HIV-positive patients with pulmonary lesions only (47 vs. 266 cells/mm 3; p < 0.0001), in HIV-positive patients with AIDS than in those without AIDS (136 vs. 398 cells/mm3; p < 0.0001) and in patients with atypical pulmonary tuberculosis than in those with other fonns of tuberculosis (31 vs. 258 cells/mm3; p < 0.01). Conclusion: Atypical forms and disseminated disease predominate among patients with advanced immunosuppression. In regions where TB prevalence is high, the presence of atypical pulmonary tuberculosis or pulmonary tuberculosis accompanied by superficial lymph node enlargement should be considered an AlDSdefining condition.

Translated title of the contributionDifferences in the clinical and radiological presentation of intrathoracic tuberculosis in the presence or absence of HIV infection
Original languagePortuguese
Pages (from-to)429-436
Number of pages8
JournalJornal Brasileiro de Pneumologia
Volume33
Issue number4
DOIs
StatePublished - 2007

Keywords

  • HIV infections
  • Pulmonary
  • Radiography
  • Thoracic
  • Tuberculosis

Fingerprint Dive into the research topics of 'Differences in the clinical and radiological presentation of intrathoracic tuberculosis in the presence or absence of HIV infection'. Together they form a unique fingerprint.

Cite this