Dietary phytoestrogens

Research output: Contribution to journalReview article

763 Citations (Scopus)

Abstract

Broadly defined, phytoestrogens include isoflavones, coumestans, and lignans. A number of these compounds have been identified in fruits, vegetables, and whole grains commonly consumed by humans. Soybeans, clover and alfalfa sprouts, and oilseeds (such as flaxseed) are the most significant dietary sources of isoflavones, coumestans, and lignans, respectively. Studies in humans, animals, and cell culture systems suggest that dietary phytoestrogens play an important role in prevention of menopausal symptoms, osteoporosis, cancer, and heart disease. Proposed mechanisms include estrogenic and antiestrogenic effects, induction of cancer cell differentiation, inhibition of tyrosine kinase and DNA topoisomerase activities, suppression of angiogenesis, and antioxidant effects. Although there currently are no dietary recommendations for individual phytoestrogens, there may be great benefit in increased consumption of plant foods.

Original languageEnglish (US)
Pages (from-to)353-381
Number of pages29
JournalAnnual Review of Nutrition
Volume17
DOIs
StatePublished - Aug 19 1997

Fingerprint

Phytoestrogens
Lignans
Isoflavones
Flax
Medicago
Type I DNA Topoisomerase
Edible Plants
Medicago sativa
Angiogenesis Inducing Agents
Soybeans
Vegetables
Protein-Tyrosine Kinases
Osteoporosis
Cell Differentiation
Heart Diseases
Fruit
Neoplasms
Estrogens
Cell Culture Techniques
Antioxidants

Keywords

  • Coumestan
  • Diet
  • Isoflavone
  • Lignan

Cite this

Dietary phytoestrogens. / Kurzer, Mindy S; Xu, Xia.

In: Annual Review of Nutrition, Vol. 17, 19.08.1997, p. 353-381.

Research output: Contribution to journalReview article

Kurzer, Mindy S ; Xu, Xia. / Dietary phytoestrogens. In: Annual Review of Nutrition. 1997 ; Vol. 17. pp. 353-381.
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