Abstract
Hypertension increased the responsiveness of spontaneously hypertensive rats (SHR) to exogenously infused prostacyclin (PGI2) at rates of 300 ng/kg/min and 1 μg/kg/min. This did not occur for angiotensin infusion. Substitution of a diet containing α-linolenic acid for the control diet to SHR abolition of the increased responsiveness to PGI2. Accompanying the abolition of the increased responsiveness to PGI2 was a significant increase in specific activity of two lysosomal hydrolases (N-acetylglucosaminadase and cathepsin D) within the aorta of SHR. These changes may reflect compensatory responses of the vasculature to protect the animal.
Original language | English (US) |
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Pages (from-to) | 235-241 |
Number of pages | 7 |
Journal | Prostaglandins and Medicine |
Volume | 5 |
Issue number | 4 |
DOIs | |
State | Published - 1980 |
Bibliographical note
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