Dietary modification of the vascular effect of prostacyclin in hypertensive rats

G. Feinberg, G. J. Trachte, M. Curtis, A. M. Lefer

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Abstract

Hypertension increased the responsiveness of spontaneously hypertensive rats (SHR) to exogenously infused prostacyclin (PGI2) at rates of 300 ng/kg/min and 1 μg/kg/min. This did not occur for angiotensin infusion. Substitution of a diet containing α-linolenic acid for the control diet to SHR abolition of the increased responsiveness to PGI2. Accompanying the abolition of the increased responsiveness to PGI2 was a significant increase in specific activity of two lysosomal hydrolases (N-acetylglucosaminadase and cathepsin D) within the aorta of SHR. These changes may reflect compensatory responses of the vasculature to protect the animal.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalProstaglandins and Medicine
Volume5
Issue number4
DOIs
StatePublished - Jan 1 1980

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