Dietary linoleic acid and risk of coronary heart disease: A systematic review and meta-analysis of prospective cohort studies

Maryam S. Farvid, Ming Ding, An Pan, Qi Sun, Stephanie E. Chiuve, Lyn M. Steffen, Walter C. Willett, Frank B. Hu

Research output: Contribution to journalArticlepeer-review

252 Scopus citations

Abstract

Background: Previous studies on intake of linoleic acid (LA), the predominant n-6 fatty acid, and coronary heart disease (CHD) risk have generated inconsistent results. We performed a systematic review and meta-analysis of prospective cohort studies to summarize the evidence regarding the relation of dietary LA intake and CHD risk.

Conclusions: In prospective observational studies, dietary LA intake is inversely associated with CHD risk in a dose- response manner. These data provide support for current recommendations to replace saturated fat with polyunsaturated fat for primary prevention of CHD.

Original languageEnglish (US)
Pages (from-to)1568-1578
Number of pages11
JournalCirculation
Volume130
Issue number18
DOIs
StatePublished - 2014

Bibliographical note

Publisher Copyright:
© 2014 American Heart Association, Inc.

Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.

Keywords

  • Cardiovascular disease
  • Coronary disease
  • Diet
  • Linoleic acid
  • Meta-analysis
  • Polyunsaturated fatty acids
  • Saturated fatty acids

Fingerprint Dive into the research topics of 'Dietary linoleic acid and risk of coronary heart disease: A systematic review and meta-analysis of prospective cohort studies'. Together they form a unique fingerprint.

Cite this