Background: Previous studies on intake of linoleic acid (LA), the predominant n-6 fatty acid, and coronary heart disease (CHD) risk have generated inconsistent results. We performed a systematic review and meta-analysis of prospective cohort studies to summarize the evidence regarding the relation of dietary LA intake and CHD risk.
Conclusions: In prospective observational studies, dietary LA intake is inversely associated with CHD risk in a dose- response manner. These data provide support for current recommendations to replace saturated fat with polyunsaturated fat for primary prevention of CHD.
Bibliographical notePublisher Copyright:
© 2014 American Heart Association, Inc.
Copyright 2015 Elsevier B.V., All rights reserved.
- Cardiovascular disease
- Coronary disease
- Linoleic acid
- Polyunsaturated fatty acids
- Saturated fatty acids