Dietary intake of soy and cruciferous vegetables and treatment-related symptoms in Chinese-American and non-Hispanic White breast cancer survivors

Sarah O Nomura, Yi Ting Hwang, Scarlett Lin Gomez, Teresa T. Fung, Shu Lan Yeh, Chiranjeev Dash, Laura Allen, Serena Philips, Leena Hilakivi-Clarke, Yun Ling Zheng, Judy Huei yu Wang

Research output: Contribution to journalArticle

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Abstract

Purpose: This project was undertaken to examine the association between dietary intake of soy or cruciferous vegetables and breast cancer treatment-related symptoms among Chinese-American (CA) and Non-Hispanic White (NHW) breast cancer survivors. Methods: This cross-sectional study included 192 CA and 173 NHW female breast cancer survivors (stages 0–III, diagnosed between 2006 and 2012) recruited from two California cancer registries, who had completed primary treatment. Patient-reported data on treatment-related symptoms and potential covariates were collected via telephone interviews. Dietary data were ascertained by mailed questionnaires. The outcomes evaluated were menopausal symptoms (hot flashes, night sweats, vaginal dryness, vaginal discharge), joint problems, fatigue, hair thinning/loss, and memory problems. Associations between soy and cruciferous vegetables and symptoms were assessed using logistic regression. Analyses were further stratified by race/ethnicity and endocrine therapy usage (non-user, tamoxifen, aromatase inhibitors). Results: Soy food and cruciferous vegetable intake ranged from no intake to 431 and 865 g/day, respectively, and was higher in CA survivors. Higher soy food intake was associated with lower odds of menopausal symptoms (≥ 24.0 vs. 0 g/day, OR 0.51, 95% CI 0.25, 1.03), and fatigue (≥ 24.0 vs. 0 g/day, OR 0.43, 95% CI 0.22, 0.84). However, when stratified by race/ethnicity, associations were statistically significant in NHW survivors only. Compared with low intake, higher cruciferous vegetable intake was associated with lower odds of experiencing menopausal symptoms (≥ 70.8 vs. OpenSPiltSPi 33.0 g/day, OR 0.50, 95% CI 0.25, 0.97) in the overall population. Conclusions: In this population of breast cancer survivors, higher soy and cruciferous vegetable intake was associated with less treatment-related menopausal symptoms and fatigue.

Original languageEnglish (US)
Pages (from-to)467-479
Number of pages13
JournalBreast Cancer Research and Treatment
Volume168
Issue number2
DOIs
StatePublished - Apr 1 2018
Externally publishedYes

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Asian Americans
Vegetables
Survivors
Breast Neoplasms
Fatigue
Soy Foods
Hot Flashes
Vaginal Discharge
Therapeutics
Aromatase Inhibitors
Sweat
Alopecia
Tamoxifen
Population
Registries
Cross-Sectional Studies
Eating
Joints
Logistic Models
Interviews

Keywords

  • Breast cancer survivors
  • Cruciferous vegetables
  • Endocrine therapy
  • Late treatment effects
  • Soy foods

PubMed: MeSH publication types

  • Journal Article

Cite this

Dietary intake of soy and cruciferous vegetables and treatment-related symptoms in Chinese-American and non-Hispanic White breast cancer survivors. / Nomura, Sarah O; Hwang, Yi Ting; Gomez, Scarlett Lin; Fung, Teresa T.; Yeh, Shu Lan; Dash, Chiranjeev; Allen, Laura; Philips, Serena; Hilakivi-Clarke, Leena; Zheng, Yun Ling; Wang, Judy Huei yu.

In: Breast Cancer Research and Treatment, Vol. 168, No. 2, 01.04.2018, p. 467-479.

Research output: Contribution to journalArticle

Nomura, SO, Hwang, YT, Gomez, SL, Fung, TT, Yeh, SL, Dash, C, Allen, L, Philips, S, Hilakivi-Clarke, L, Zheng, YL & Wang, JHY 2018, 'Dietary intake of soy and cruciferous vegetables and treatment-related symptoms in Chinese-American and non-Hispanic White breast cancer survivors', Breast Cancer Research and Treatment, vol. 168, no. 2, pp. 467-479. https://doi.org/10.1007/s10549-017-4578-9
Nomura, Sarah O ; Hwang, Yi Ting ; Gomez, Scarlett Lin ; Fung, Teresa T. ; Yeh, Shu Lan ; Dash, Chiranjeev ; Allen, Laura ; Philips, Serena ; Hilakivi-Clarke, Leena ; Zheng, Yun Ling ; Wang, Judy Huei yu. / Dietary intake of soy and cruciferous vegetables and treatment-related symptoms in Chinese-American and non-Hispanic White breast cancer survivors. In: Breast Cancer Research and Treatment. 2018 ; Vol. 168, No. 2. pp. 467-479.
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abstract = "Purpose: This project was undertaken to examine the association between dietary intake of soy or cruciferous vegetables and breast cancer treatment-related symptoms among Chinese-American (CA) and Non-Hispanic White (NHW) breast cancer survivors. Methods: This cross-sectional study included 192 CA and 173 NHW female breast cancer survivors (stages 0–III, diagnosed between 2006 and 2012) recruited from two California cancer registries, who had completed primary treatment. Patient-reported data on treatment-related symptoms and potential covariates were collected via telephone interviews. Dietary data were ascertained by mailed questionnaires. The outcomes evaluated were menopausal symptoms (hot flashes, night sweats, vaginal dryness, vaginal discharge), joint problems, fatigue, hair thinning/loss, and memory problems. Associations between soy and cruciferous vegetables and symptoms were assessed using logistic regression. Analyses were further stratified by race/ethnicity and endocrine therapy usage (non-user, tamoxifen, aromatase inhibitors). Results: Soy food and cruciferous vegetable intake ranged from no intake to 431 and 865 g/day, respectively, and was higher in CA survivors. Higher soy food intake was associated with lower odds of menopausal symptoms (≥ 24.0 vs. 0 g/day, OR 0.51, 95{\%} CI 0.25, 1.03), and fatigue (≥ 24.0 vs. 0 g/day, OR 0.43, 95{\%} CI 0.22, 0.84). However, when stratified by race/ethnicity, associations were statistically significant in NHW survivors only. Compared with low intake, higher cruciferous vegetable intake was associated with lower odds of experiencing menopausal symptoms (≥ 70.8 vs. OpenSPiltSPi 33.0 g/day, OR 0.50, 95{\%} CI 0.25, 0.97) in the overall population. Conclusions: In this population of breast cancer survivors, higher soy and cruciferous vegetable intake was associated with less treatment-related menopausal symptoms and fatigue.",
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AU - Gomez, Scarlett Lin

AU - Fung, Teresa T.

AU - Yeh, Shu Lan

AU - Dash, Chiranjeev

AU - Allen, Laura

AU - Philips, Serena

AU - Hilakivi-Clarke, Leena

AU - Zheng, Yun Ling

AU - Wang, Judy Huei yu

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N2 - Purpose: This project was undertaken to examine the association between dietary intake of soy or cruciferous vegetables and breast cancer treatment-related symptoms among Chinese-American (CA) and Non-Hispanic White (NHW) breast cancer survivors. Methods: This cross-sectional study included 192 CA and 173 NHW female breast cancer survivors (stages 0–III, diagnosed between 2006 and 2012) recruited from two California cancer registries, who had completed primary treatment. Patient-reported data on treatment-related symptoms and potential covariates were collected via telephone interviews. Dietary data were ascertained by mailed questionnaires. The outcomes evaluated were menopausal symptoms (hot flashes, night sweats, vaginal dryness, vaginal discharge), joint problems, fatigue, hair thinning/loss, and memory problems. Associations between soy and cruciferous vegetables and symptoms were assessed using logistic regression. Analyses were further stratified by race/ethnicity and endocrine therapy usage (non-user, tamoxifen, aromatase inhibitors). Results: Soy food and cruciferous vegetable intake ranged from no intake to 431 and 865 g/day, respectively, and was higher in CA survivors. Higher soy food intake was associated with lower odds of menopausal symptoms (≥ 24.0 vs. 0 g/day, OR 0.51, 95% CI 0.25, 1.03), and fatigue (≥ 24.0 vs. 0 g/day, OR 0.43, 95% CI 0.22, 0.84). However, when stratified by race/ethnicity, associations were statistically significant in NHW survivors only. Compared with low intake, higher cruciferous vegetable intake was associated with lower odds of experiencing menopausal symptoms (≥ 70.8 vs. OpenSPiltSPi 33.0 g/day, OR 0.50, 95% CI 0.25, 0.97) in the overall population. Conclusions: In this population of breast cancer survivors, higher soy and cruciferous vegetable intake was associated with less treatment-related menopausal symptoms and fatigue.

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KW - Late treatment effects

KW - Soy foods

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